Efficacy of lifestyle interventions on clinical and neuroimaging outcomes in elderly

Elena Rolandi, Giovanni Battista Frisoni, Enrica Cavedo

Research output: Contribution to journalArticlepeer-review


The prevalence of Alzheimer's disease (AD) is constantly growing worldwide in absence of any effective treatment. Methodology and technique advancements facilitated the early diagnosis of AD leading to a shift toward preclinical AD stages investigation in order to delay the disease onset in individuals at risk for AD. Recent evidence demonstrating the aging related multifactorial nature of AD supported the hypothesis that modifiable environmental factors can accelerate or delay the disease onset. In particular, healthy dietary habits, constant physical and cognitive activities are associated with reduced brain atrophy, amyloid load and incidence of AD cases. Due to these promising results, an emerging field of studies is currently investigating the efficacy of interventions addressing different lifestyle habits in cognitive intact elderly individuals as a potential preventive strategy against AD onset.We provide a critical overview of the current evidence on nonpharmacologic treatments in elderly individuals, discussing their efficacy on clinical and neuroimaging outcomes and identifying current methodological issues. Future perspectives, relevant for the scientific community and the worldwide public health institutes will be further discussed.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalAgeing Research Reviews
Publication statusPublished - Jan 1 2016


  • Alzheimer's disease
  • Clinical outcomes
  • Lifestyle
  • Neuroimaging
  • Nonpharmacological interventions
  • Prevention trials

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Biotechnology
  • Molecular Biology
  • Neurology


Dive into the research topics of 'Efficacy of lifestyle interventions on clinical and neuroimaging outcomes in elderly'. Together they form a unique fingerprint.

Cite this