Efficacy of lithium treatment in Kleine-Levin syndrome

F. Muratori, N. Bertini, G. Masi

Research output: Contribution to journalArticlepeer-review


The Kleine-Levin syndrome (KLS) is characterized by periodic, sudden-onset episodes of hypersomnia, compulsive hyperphagia, and behavioral-emotional symptoms, lasting from a few days to a few weeks, with complete remission in the intercritical periods. We report on efficacy of lithium treatment in a highly recurring form of the disorder in a 17-year-old male adolescent. The decreasing severity of the disorder paralleled the progressive increase of lithium dosage, up to 0.9 mEq I-1. Implications regarding the pharmacological treatment of this neglected disorder are discussed.

Original languageEnglish
Pages (from-to)232-233
Number of pages2
JournalEuropean Psychiatry
Issue number4
Publication statusPublished - Jul 2002


  • Adolescence
  • Kleine-Levin syndrome
  • Lithium

ASJC Scopus subject areas

  • Psychiatry and Mental health


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