Efficacy of liver transplantation in patients with primary biliary cirrhosis

B. H. Markus, E. R. Dickson, P. M. Grambsch, T. R. Fleming, V. Mazzaferro, G. B G Klintmalm, R. H. Wiesner, D. H. Van Thiel, T. E. Starzl

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Abstract

No controlled trials have been performed to assess the efficacy of liver transplantation. Because of the marked improvement in survival after liver transplantation since 1981, random assignment of patients to a control group not undergoing transplantation is considered clinically inappropriate. To assess the efficacy of liver transplantation in patients with primary biliary cirrhosis, we compared survival in 161 patients with this diagnosis who had undergone a liver transplantation with survival in patients with the same diagnosis who had not been treated conservatively. The comparison was performed with use of a recently developed statistical technique, the Mayo model. All patients had undergone liver transplantation between March 1980 and June 1987 and were followed for a median of 25 months. Three months after liver transplantation, the Kaplan-Meier survival probabilities in the recipients were substantially higher than the Mayo-model 'simulated control' survival probabilities (P <0.001). At two years, the Kaplan-Meier survival probability was 0.74, whereas the mean Mayo-model survival probability was 0.31. The patients who were at low risk according to the Mayo model had the best probability of survival after liver transplantation; however, patients at all risk levels who had undergone liver transplantation had higher probabilities of survival than those who had not. We conclude that liver transplantation is an efficacious treatment in patients with advanced primary biliary cirrhosis.

Original languageEnglish
Pages (from-to)1709-1713
Number of pages5
JournalNew England Journal of Medicine
Volume320
Issue number26
Publication statusPublished - 1989

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Biliary Liver Cirrhosis
Liver Transplantation
Survival
Transplantation
Control Groups

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Markus, B. H., Dickson, E. R., Grambsch, P. M., Fleming, T. R., Mazzaferro, V., Klintmalm, G. B. G., ... Starzl, T. E. (1989). Efficacy of liver transplantation in patients with primary biliary cirrhosis. New England Journal of Medicine, 320(26), 1709-1713.

Efficacy of liver transplantation in patients with primary biliary cirrhosis. / Markus, B. H.; Dickson, E. R.; Grambsch, P. M.; Fleming, T. R.; Mazzaferro, V.; Klintmalm, G. B G; Wiesner, R. H.; Van Thiel, D. H.; Starzl, T. E.

In: New England Journal of Medicine, Vol. 320, No. 26, 1989, p. 1709-1713.

Research output: Contribution to journalArticle

Markus, BH, Dickson, ER, Grambsch, PM, Fleming, TR, Mazzaferro, V, Klintmalm, GBG, Wiesner, RH, Van Thiel, DH & Starzl, TE 1989, 'Efficacy of liver transplantation in patients with primary biliary cirrhosis', New England Journal of Medicine, vol. 320, no. 26, pp. 1709-1713.
Markus BH, Dickson ER, Grambsch PM, Fleming TR, Mazzaferro V, Klintmalm GBG et al. Efficacy of liver transplantation in patients with primary biliary cirrhosis. New England Journal of Medicine. 1989;320(26):1709-1713.
Markus, B. H. ; Dickson, E. R. ; Grambsch, P. M. ; Fleming, T. R. ; Mazzaferro, V. ; Klintmalm, G. B G ; Wiesner, R. H. ; Van Thiel, D. H. ; Starzl, T. E. / Efficacy of liver transplantation in patients with primary biliary cirrhosis. In: New England Journal of Medicine. 1989 ; Vol. 320, No. 26. pp. 1709-1713.
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