Efficacy of long-term growth hormone therapy in short non-growth hormone-deficient children

Lucia Schena, Cristina Meazza, Sara Pagani, Valeria Paganelli, Elena Bozzola, Carmine Tinelli, Fabio Buzi, Mauro Bozzola

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In recent years, several studies have been published showing different responses to growth hormone (GH) treatment in idiopathic short stature children. The aim of the present study was to investigate whether non-growth-hormone-deficient (non-GHD) short children could benefit from long-term GH treatment as GHD patients. We enrolled 22 prepubertal children and 22 age- and sex-matched GHD patients, with comparable height, body mass index (BMI), bone age, and insulin-like growth factor 1 (IGF-I) circulating levels. The patients were treated with recombinant human GH (rhGH) and followed until they reach adult height. During GH treatment, the two groups grew in parallel, reaching the same final height-standard deviation score (SDS) and the same height gain. On the contrary, we found significantly lower IGF-I serum concentrations in non-GHD patients than in GHD ones, at the end of therapy (p=0.0055). In our study, the response to GH treatment in short non-GHD patients proved to be similar to that in GHD ones. However, a careful selection of short non-GHD children to be treated with GH would better justify the cost of long-term GH therapy.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalJournal of Pediatric Endocrinology and Metabolism
Volume30
Issue number2
DOIs
Publication statusPublished - Feb 1 2017

Fingerprint

Growth Hormone
Hormones
Insulin-Like Growth Factor I
Therapeutics
Human Growth Hormone
Somatomedins
Body Mass Index
Costs and Cost Analysis
Bone and Bones
Serum

Keywords

  • Adult height
  • Growth hormone
  • Growth hormone treatment
  • Insulin-like growth factor-I
  • Short stature

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Efficacy of long-term growth hormone therapy in short non-growth hormone-deficient children. / Schena, Lucia; Meazza, Cristina; Pagani, Sara; Paganelli, Valeria; Bozzola, Elena; Tinelli, Carmine; Buzi, Fabio; Bozzola, Mauro.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 30, No. 2, 01.02.2017, p. 197-201.

Research output: Contribution to journalArticle

@article{5d724cb19485435d8f6d4d2d14d2f7c1,
title = "Efficacy of long-term growth hormone therapy in short non-growth hormone-deficient children",
abstract = "In recent years, several studies have been published showing different responses to growth hormone (GH) treatment in idiopathic short stature children. The aim of the present study was to investigate whether non-growth-hormone-deficient (non-GHD) short children could benefit from long-term GH treatment as GHD patients. We enrolled 22 prepubertal children and 22 age- and sex-matched GHD patients, with comparable height, body mass index (BMI), bone age, and insulin-like growth factor 1 (IGF-I) circulating levels. The patients were treated with recombinant human GH (rhGH) and followed until they reach adult height. During GH treatment, the two groups grew in parallel, reaching the same final height-standard deviation score (SDS) and the same height gain. On the contrary, we found significantly lower IGF-I serum concentrations in non-GHD patients than in GHD ones, at the end of therapy (p=0.0055). In our study, the response to GH treatment in short non-GHD patients proved to be similar to that in GHD ones. However, a careful selection of short non-GHD children to be treated with GH would better justify the cost of long-term GH therapy.",
keywords = "Adult height, Growth hormone, Growth hormone treatment, Insulin-like growth factor-I, Short stature",
author = "Lucia Schena and Cristina Meazza and Sara Pagani and Valeria Paganelli and Elena Bozzola and Carmine Tinelli and Fabio Buzi and Mauro Bozzola",
year = "2017",
month = "2",
day = "1",
doi = "10.1515/jpem-2016-0297",
language = "English",
volume = "30",
pages = "197--201",
journal = "Journal of Pediatric Endocrinology and Metabolism",
issn = "0334-018X",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "2",

}

TY - JOUR

T1 - Efficacy of long-term growth hormone therapy in short non-growth hormone-deficient children

AU - Schena, Lucia

AU - Meazza, Cristina

AU - Pagani, Sara

AU - Paganelli, Valeria

AU - Bozzola, Elena

AU - Tinelli, Carmine

AU - Buzi, Fabio

AU - Bozzola, Mauro

PY - 2017/2/1

Y1 - 2017/2/1

N2 - In recent years, several studies have been published showing different responses to growth hormone (GH) treatment in idiopathic short stature children. The aim of the present study was to investigate whether non-growth-hormone-deficient (non-GHD) short children could benefit from long-term GH treatment as GHD patients. We enrolled 22 prepubertal children and 22 age- and sex-matched GHD patients, with comparable height, body mass index (BMI), bone age, and insulin-like growth factor 1 (IGF-I) circulating levels. The patients were treated with recombinant human GH (rhGH) and followed until they reach adult height. During GH treatment, the two groups grew in parallel, reaching the same final height-standard deviation score (SDS) and the same height gain. On the contrary, we found significantly lower IGF-I serum concentrations in non-GHD patients than in GHD ones, at the end of therapy (p=0.0055). In our study, the response to GH treatment in short non-GHD patients proved to be similar to that in GHD ones. However, a careful selection of short non-GHD children to be treated with GH would better justify the cost of long-term GH therapy.

AB - In recent years, several studies have been published showing different responses to growth hormone (GH) treatment in idiopathic short stature children. The aim of the present study was to investigate whether non-growth-hormone-deficient (non-GHD) short children could benefit from long-term GH treatment as GHD patients. We enrolled 22 prepubertal children and 22 age- and sex-matched GHD patients, with comparable height, body mass index (BMI), bone age, and insulin-like growth factor 1 (IGF-I) circulating levels. The patients were treated with recombinant human GH (rhGH) and followed until they reach adult height. During GH treatment, the two groups grew in parallel, reaching the same final height-standard deviation score (SDS) and the same height gain. On the contrary, we found significantly lower IGF-I serum concentrations in non-GHD patients than in GHD ones, at the end of therapy (p=0.0055). In our study, the response to GH treatment in short non-GHD patients proved to be similar to that in GHD ones. However, a careful selection of short non-GHD children to be treated with GH would better justify the cost of long-term GH therapy.

KW - Adult height

KW - Growth hormone

KW - Growth hormone treatment

KW - Insulin-like growth factor-I

KW - Short stature

UR - http://www.scopus.com/inward/record.url?scp=85011798148&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011798148&partnerID=8YFLogxK

U2 - 10.1515/jpem-2016-0297

DO - 10.1515/jpem-2016-0297

M3 - Article

VL - 30

SP - 197

EP - 201

JO - Journal of Pediatric Endocrinology and Metabolism

JF - Journal of Pediatric Endocrinology and Metabolism

SN - 0334-018X

IS - 2

ER -