Efficacy of low-dose rituximab for mixed cryoglobulinemia

Marcella Visentini, Massimo Granata, Maria Luisa Veneziano, Federica Borghese, Maurizio Carlesimo, Fulvia Pimpinelli, Massimo Fiorilli, Milvia Casato

Research output: Contribution to journalArticlepeer-review


Rituximab at 375 mg/m2 × 4 is effective for refractory HCV-related mixed cryoglobulinemia. We conducted a pilot study to assess the efficacy of a lower dosage, 250 mg/m2 × 2. Six consecutive patients with mixed cryoglobulinemia were treated. All patients had severe or life-threatening disease manifestations, including necrotizing skin ulcers, renal disease, hyperviscosity or intestinal vasculitis. Four of five evaluable patients (excluding one early death) had > 80% decrease of cryocrit and remission of vasculitis at the end of a 22- to 55-week (median 40) follow-up. The non-responder failed to respond to additional rituximab treatment, suggesting intrinsic resistance rather than insufficient dosage as the cause of treatment failure. No sustained increase of HCV viremia after rituximab was observed. Rituximab at 250 mg/m2 × 2 may be as effective as at 375 mg/m2 × 4 for treating mixed cryoglobulinemia. Larger studies are required to assess the efficacy of low-dose rituximab.

Original languageEnglish
Pages (from-to)30-33
Number of pages4
JournalClinical Immunology
Issue number1
Publication statusPublished - Oct 2007


  • Cryoglobulinemia
  • Hepatitis C virus
  • Rituximab
  • Vasculitis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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