Efficacy of maintenance therapy with topical boric acid in comparison with oral itraconazole in the treatment of recurrent vulvovaginal candidiasis

Secondo Guaschino, Francesco De Seta, Andrea Sartore, Giuseppe Ricci, Davide De Santo, Monica Piccoli, Salvatore Alberico

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Our purpose was to examine the efficacy of a topical long-term treatment with boric acid versus an oral long-term treatment (itraconazole) in the cure and prevention of recurrent vulvovaginal candidiasis. STUDY DESIGN: A prospective, nonrandomized study of patients affected by recurrent vulvovaginal candidiasis was undertaken. In 3 years we recruited 22 consecutive patients who underwent therapy with itraconazole (group 1) or boric acid (group 2). Women were followed up for 1 year, with clinic and microbiologic controls after 1, 3, 6, and 12 months after the first visit. RESULTS: During the treatment, the positive culture results (15.1% vs 12.1%) and the signs and symptoms (33.3% vs 24.2%) were similar within the 2 groups, with no significant statistical difference. With the withdrawal, after 6 months relapses were common in the 2 groups (54.5%). CONCLUSlONS: Boric acid seems to be a valid and promising therapy both in the cure of the vaginal infection and in the prevention of relapses of recurrent vulvovaginal candidiasis, but its efficacy ends with the suspension of the therapy.

Original languageEnglish
Pages (from-to)598-602
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume184
Issue number4
DOIs
Publication statusPublished - 2001

Keywords

  • Boric acid
  • Itraconazole
  • Prevention
  • Recurrent vulvovaginal candidiasis

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

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