Efficacy of Modified Atkins Ketogenic Diet in Chronic Cluster Headache: An Open-Label, Single-Arm, Clinical Trial

Cherubino Di Lorenzo, Gianluca Coppola, Davide Di Lenola, Maurizio Evangelista, Giulio Sirianni, Paolo Rossi, Giorgio Di Lorenzo, Mariano Serrao, Francesco Pierelli

Research output: Contribution to journalArticle

Abstract

Introduction: Drug-resistant cluster headache (CH) is still an open clinical challenge. Recently, our group observed the clinical efficacy of a ketogenic diet (KD), usually adopted to treat drug-resistant epilepsies, on migraine.

Aim: Here, we aim to detect the effect of KD in a group of drug-resistant chronic CH (CCH) patients.

Materials and methods: Eighteen drug-resistant CCH patients underwent a 12-week KD (Modified Atkins Diet, MAD), and the clinical response was evaluated in terms of response (≥50% attack reduction).

Results: Of the 18 CCH patients, 15 were considered responders to the diet (11 experienced a full resolution of headache, and 4 had a headache reduction of at least 50% in terms of mean monthly number of attacks during the diet). The mean monthly number of attacks for each patient at the baseline was 108.71 (SD = 81.71); at the end of the third month of diet, it was reduced to 31.44 (SD = 84.61).

Conclusion: We observed for the first time that a 3-month ketogenesis ameliorates clinical features of CCH.

Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03244735.

Original languageEnglish
Pages (from-to)64
Number of pages5
JournalFrontiers in Neurology
Volume9
DOIs
Publication statusPublished - 2018

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Ketogenic Diet
Carbohydrate-Restricted Diet
Cluster Headache
Clinical Trials
Diet
Headache
Pharmaceutical Preparations
Migraine Disorders

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Efficacy of Modified Atkins Ketogenic Diet in Chronic Cluster Headache : An Open-Label, Single-Arm, Clinical Trial. / Di Lorenzo, Cherubino; Coppola, Gianluca; Di Lenola, Davide; Evangelista, Maurizio; Sirianni, Giulio; Rossi, Paolo; Di Lorenzo, Giorgio; Serrao, Mariano; Pierelli, Francesco.

In: Frontiers in Neurology, Vol. 9, 2018, p. 64.

Research output: Contribution to journalArticle

Di Lorenzo, Cherubino ; Coppola, Gianluca ; Di Lenola, Davide ; Evangelista, Maurizio ; Sirianni, Giulio ; Rossi, Paolo ; Di Lorenzo, Giorgio ; Serrao, Mariano ; Pierelli, Francesco. / Efficacy of Modified Atkins Ketogenic Diet in Chronic Cluster Headache : An Open-Label, Single-Arm, Clinical Trial. In: Frontiers in Neurology. 2018 ; Vol. 9. pp. 64.
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abstract = "Introduction: Drug-resistant cluster headache (CH) is still an open clinical challenge. Recently, our group observed the clinical efficacy of a ketogenic diet (KD), usually adopted to treat drug-resistant epilepsies, on migraine.Aim: Here, we aim to detect the effect of KD in a group of drug-resistant chronic CH (CCH) patients.Materials and methods: Eighteen drug-resistant CCH patients underwent a 12-week KD (Modified Atkins Diet, MAD), and the clinical response was evaluated in terms of response (≥50{\%} attack reduction).Results: Of the 18 CCH patients, 15 were considered responders to the diet (11 experienced a full resolution of headache, and 4 had a headache reduction of at least 50{\%} in terms of mean monthly number of attacks during the diet). The mean monthly number of attacks for each patient at the baseline was 108.71 (SD = 81.71); at the end of the third month of diet, it was reduced to 31.44 (SD = 84.61).Conclusion: We observed for the first time that a 3-month ketogenesis ameliorates clinical features of CCH.Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03244735.",
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T2 - An Open-Label, Single-Arm, Clinical Trial

AU - Di Lorenzo, Cherubino

AU - Coppola, Gianluca

AU - Di Lenola, Davide

AU - Evangelista, Maurizio

AU - Sirianni, Giulio

AU - Rossi, Paolo

AU - Di Lorenzo, Giorgio

AU - Serrao, Mariano

AU - Pierelli, Francesco

PY - 2018

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N2 - Introduction: Drug-resistant cluster headache (CH) is still an open clinical challenge. Recently, our group observed the clinical efficacy of a ketogenic diet (KD), usually adopted to treat drug-resistant epilepsies, on migraine.Aim: Here, we aim to detect the effect of KD in a group of drug-resistant chronic CH (CCH) patients.Materials and methods: Eighteen drug-resistant CCH patients underwent a 12-week KD (Modified Atkins Diet, MAD), and the clinical response was evaluated in terms of response (≥50% attack reduction).Results: Of the 18 CCH patients, 15 were considered responders to the diet (11 experienced a full resolution of headache, and 4 had a headache reduction of at least 50% in terms of mean monthly number of attacks during the diet). The mean monthly number of attacks for each patient at the baseline was 108.71 (SD = 81.71); at the end of the third month of diet, it was reduced to 31.44 (SD = 84.61).Conclusion: We observed for the first time that a 3-month ketogenesis ameliorates clinical features of CCH.Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03244735.

AB - Introduction: Drug-resistant cluster headache (CH) is still an open clinical challenge. Recently, our group observed the clinical efficacy of a ketogenic diet (KD), usually adopted to treat drug-resistant epilepsies, on migraine.Aim: Here, we aim to detect the effect of KD in a group of drug-resistant chronic CH (CCH) patients.Materials and methods: Eighteen drug-resistant CCH patients underwent a 12-week KD (Modified Atkins Diet, MAD), and the clinical response was evaluated in terms of response (≥50% attack reduction).Results: Of the 18 CCH patients, 15 were considered responders to the diet (11 experienced a full resolution of headache, and 4 had a headache reduction of at least 50% in terms of mean monthly number of attacks during the diet). The mean monthly number of attacks for each patient at the baseline was 108.71 (SD = 81.71); at the end of the third month of diet, it was reduced to 31.44 (SD = 84.61).Conclusion: We observed for the first time that a 3-month ketogenesis ameliorates clinical features of CCH.Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03244735.

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JO - Frontiers in Neurology

JF - Frontiers in Neurology

SN - 1664-2295

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