Efficacy of n-3 polyunsaturated fatty acids according to clinical characteristics of patients with recent myocardial infarction: Insights from the GISSI-Prevenzione trial

Roberto Marchioli, Rosa Maria Marfisi, Giovanna Borrelli, Carmelo Chieffo, Maria Grazia Franzosi, Giacomo Levantesi, Aldo Pietro Maggioni, Gian Luigi Nicolosi, Marco Scarano, Maria Giuseppina Silletta, Carlo Schweiger, Luigi Tavazzi, Gianni Tognoni

Research output: Contribution to journalArticle

Abstract

The GISSI-Prevenzione trial established the efficacy of n-3 polyunsaturated fatty acids (PUFAs) for reducing mortality in patients after recent myocardial infarction. The generalisability of such results to clinical practice could vary according to other individual patient characteristics. We analysed the GISSI-Prevenzione database to assess whether other major risk factors, comorbidities, dietary habits, or medications could interact with the efficacy of n-3 PUFA treatment to reduce total mortality. We found no evidence that concomitant disease states, habits, or interventions altered the therapeutic benefit of n-3 PUFA consumption in survivors of recent myocardial infarction.

Original languageEnglish
JournalJournal of Cardiovascular Medicine
Volume8
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Coronary heart disease
  • n-3 polyunsaturated fatty acids
  • Randomised controlled trial

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Marchioli, R., Marfisi, R. M., Borrelli, G., Chieffo, C., Franzosi, M. G., Levantesi, G., Maggioni, A. P., Nicolosi, G. L., Scarano, M., Silletta, M. G., Schweiger, C., Tavazzi, L., & Tognoni, G. (2007). Efficacy of n-3 polyunsaturated fatty acids according to clinical characteristics of patients with recent myocardial infarction: Insights from the GISSI-Prevenzione trial. Journal of Cardiovascular Medicine, 8(SUPPL. 1). https://doi.org/10.2459/01.JCM.0000289271.80180.b6