Efficacy of noninvasive tests in the diagnosis of Helicobacter pylori infection in pediatric patients

Tamara Sabbi, Paola De Angelis, Franco Colistro, Luigi Dall'Oglio, Giovanni Federici Di Abriola, Massimo Castro

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Helicobacter pylori infection is likely acquired in childhood. Helicobacter pylori is recognized as a cause of gastritis and peptic ulcer. Objective: To investigate some noninvasive tests, particularly H pylori fecal antigen, for the diagnosis of H pylori infection in comparison with the gold-standard invasive test, esophagogastroduodenoscopy with biopsy. Methods: We studied 250 patients (102 male; age range, 3-18 years) who underwent esophagogastroduodenoscopy with biopsy (histologic examination and rapid urease test) for a suspicious upper gastrointestinal disease; in all of them, fecal H pylori antigen, serum H pylori immunoglobulin G, and cytotoxin-associated gene product A immunoglobulin G were measured. Sensitivity and specificity of noninvasive tests were compared with those of the gold-standard esophagogastroduodenoscopy with biopsy. Results: Ninety-three patients (37%) had positive histopathologic (Giemsa staining) and rapid urease test results. The H pylori fecal antigen revealed a sensitivity of 97%, a specificity of 98%, a positive predictive value of 97%, and a negative predictive value of 98%; serum H pylori immunoglobulin G had a sensitivity of 86%, a specificity of 80%, a positive predictive value of 72%, and a negative predictive value of 90%; and serum cytotoxin-associated gene product A immunoglobulin G had a sensitivity of 83%, a specificity of 80%, a positive predictive value of 71%, and a negative predictive value of 89%. Conclusions: Our study demonstrates that among noninvasive and easily applicable tests, particularly in small children, H pylori fecal test is simple, suitable, and has high accuracy for the screening of H pylori-positive patients.

Original languageEnglish
Pages (from-to)238-241
Number of pages4
JournalArchives of Pediatrics and Adolescent Medicine
Volume159
Issue number3
DOIs
Publication statusPublished - Mar 2005

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Pylorus
Helicobacter Infections
Helicobacter pylori
Pediatrics
Digestive System Endoscopy
Immunoglobulin G
Urease
Cytotoxins
Biopsy
Gold
Serum
Gastrointestinal Diseases
Gastritis
Peptic Ulcer
Genes
Staining and Labeling
Antigens
Sensitivity and Specificity
Infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Efficacy of noninvasive tests in the diagnosis of Helicobacter pylori infection in pediatric patients. / Sabbi, Tamara; De Angelis, Paola; Colistro, Franco; Dall'Oglio, Luigi; Di Abriola, Giovanni Federici; Castro, Massimo.

In: Archives of Pediatrics and Adolescent Medicine, Vol. 159, No. 3, 03.2005, p. 238-241.

Research output: Contribution to journalArticle

Sabbi, Tamara ; De Angelis, Paola ; Colistro, Franco ; Dall'Oglio, Luigi ; Di Abriola, Giovanni Federici ; Castro, Massimo. / Efficacy of noninvasive tests in the diagnosis of Helicobacter pylori infection in pediatric patients. In: Archives of Pediatrics and Adolescent Medicine. 2005 ; Vol. 159, No. 3. pp. 238-241.
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