Efficacy of photopheresis extracorporeal procedure as single treatment for severe chronic GVHD: A case report

Federica Gigli, Angelo Gardellini, Aleksandra Babic, Sarah Jane Liptrott, Luca Castagna, Giovanni Martinelli, Daniele Laszlo

Research output: Contribution to journalArticle

Abstract

Allogeneic hematopoietic stem cell transplantation is the only potentially curative therapeutic option for many malignant and nonmalignant hematologic disorders. Despite this, several factors unfavorably affect the outcome of this procedure and in particular chronic graft-versus-host disease (cGVHD) remains the principal cause of morbidity after allogeneic transplantation. Here we present our experience regarding a patient affected by extensive chronic GVHD (cGVHD) treated only with extracorporeal photopheresis procedure (ECP) as first line treatment. The patient, presenting an high risk myelodysplastic syndrome (MDS), underwent an allogeneic peripheral stem cells transplantation. About 2. months after transplantation she experienced a hematological and clinical relapse of MDS. After reinduction therapy with azacitidine she obtained a second complete remission. Because of the risk of relapse related to a strong immunosuppressant therapy and the previous infectious complication, we decided to start a treatment with ECP alone for cGVHD. After six procedure the patient obtained a complete resolution of all signs and symptoms of the cGVHD. This experience may support the possibility to use only an immunomodulant treatment like ECP for the cGVHD, reducing the risk of complications of prolonged immunosuppressant treatment.

Original languageEnglish
Pages (from-to)205-207
Number of pages3
JournalTransfusion and Apheresis Science
Volume49
Issue number2
DOIs
Publication statusPublished - Oct 2013

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Keywords

  • Allogeneic stem cells transplantation
  • Chronic GVHD
  • Extracorporeal photopheresis procedure

ASJC Scopus subject areas

  • Hematology

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