Efficacy of SH U 508 A (Levovist®) in color Doppler ultrasonography of hepatocellular carcinoma vascularization

E. Angeli, R. Carpanelli, G. Crespi, A. Zanello, S. Sironi, A. Del Maschio

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

To assess the efficacy of a new US contrast agent [SH U 508 A (Levovist®), Schering] in evaluating hepatocellular carcinoma (HCC) vascularization, 38 patients with 43 lesions were submitted to color Doppler US before and after i.v. contrast medium administration. Four patients were studied after arterial chemoembolization. The patients had been selected on the basis of suboptimal color Doppler signals on baseline images. Each patient received two to four injections of Levovist® in standard doses. Tumor vascularization was qualitatively graded on a 0-3 scale. Twelve tumors (27.9%) appeared avascular at baseline examinations, while 31 (72.1%) exhibited low to moderate flow signals. After contrast agent administration, color Doppler signals were markedly enhanced in 35/43 lesions (81.4%), lasting 40 to 240 seconds. The lack of enhancement was related to tumor hypovascularity (necrosis at CT), portal vein thrombosis, deep location and successful chemoembolization. The detection of flow signals in chemoembolized tumors was explained by the persistence of viable tumor tissue. After Levovist® administration, flow signals were detectable in 97.6% of the HCCs. Therefore, Levovist® proved to be an effective tool for color Doppler evaluation of HCC vascularization.

Original languageEnglish
Pages (from-to)24-31
Number of pages8
JournalRadiologia Medica
Volume87
Issue number5 SUPPL. 1
Publication statusPublished - 1994

Fingerprint

Doppler Color Ultrasonography
Hepatocellular Carcinoma
Color
Contrast Media
Neoplasms
Portal Vein
Thrombosis
Necrosis
SHU 508
Injections

Keywords

  • HCC, Levovist®-enhanced color Doppler US
  • liver HCC

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Angeli, E., Carpanelli, R., Crespi, G., Zanello, A., Sironi, S., & Del Maschio, A. (1994). Efficacy of SH U 508 A (Levovist®) in color Doppler ultrasonography of hepatocellular carcinoma vascularization. Radiologia Medica, 87(5 SUPPL. 1), 24-31.

Efficacy of SH U 508 A (Levovist®) in color Doppler ultrasonography of hepatocellular carcinoma vascularization. / Angeli, E.; Carpanelli, R.; Crespi, G.; Zanello, A.; Sironi, S.; Del Maschio, A.

In: Radiologia Medica, Vol. 87, No. 5 SUPPL. 1, 1994, p. 24-31.

Research output: Contribution to journalArticle

Angeli, E, Carpanelli, R, Crespi, G, Zanello, A, Sironi, S & Del Maschio, A 1994, 'Efficacy of SH U 508 A (Levovist®) in color Doppler ultrasonography of hepatocellular carcinoma vascularization', Radiologia Medica, vol. 87, no. 5 SUPPL. 1, pp. 24-31.
Angeli, E. ; Carpanelli, R. ; Crespi, G. ; Zanello, A. ; Sironi, S. ; Del Maschio, A. / Efficacy of SH U 508 A (Levovist®) in color Doppler ultrasonography of hepatocellular carcinoma vascularization. In: Radiologia Medica. 1994 ; Vol. 87, No. 5 SUPPL. 1. pp. 24-31.
@article{f399a6e474f7461984943e3d353ec23e,
title = "Efficacy of SH U 508 A (Levovist{\circledR}) in color Doppler ultrasonography of hepatocellular carcinoma vascularization",
abstract = "To assess the efficacy of a new US contrast agent [SH U 508 A (Levovist{\circledR}), Schering] in evaluating hepatocellular carcinoma (HCC) vascularization, 38 patients with 43 lesions were submitted to color Doppler US before and after i.v. contrast medium administration. Four patients were studied after arterial chemoembolization. The patients had been selected on the basis of suboptimal color Doppler signals on baseline images. Each patient received two to four injections of Levovist{\circledR} in standard doses. Tumor vascularization was qualitatively graded on a 0-3 scale. Twelve tumors (27.9{\%}) appeared avascular at baseline examinations, while 31 (72.1{\%}) exhibited low to moderate flow signals. After contrast agent administration, color Doppler signals were markedly enhanced in 35/43 lesions (81.4{\%}), lasting 40 to 240 seconds. The lack of enhancement was related to tumor hypovascularity (necrosis at CT), portal vein thrombosis, deep location and successful chemoembolization. The detection of flow signals in chemoembolized tumors was explained by the persistence of viable tumor tissue. After Levovist{\circledR} administration, flow signals were detectable in 97.6{\%} of the HCCs. Therefore, Levovist{\circledR} proved to be an effective tool for color Doppler evaluation of HCC vascularization.",
keywords = "HCC, Levovist{\circledR}-enhanced color Doppler US, liver HCC",
author = "E. Angeli and R. Carpanelli and G. Crespi and A. Zanello and S. Sironi and {Del Maschio}, A.",
year = "1994",
language = "English",
volume = "87",
pages = "24--31",
journal = "Radiologia Medica",
issn = "0033-8362",
publisher = "Springer-Verlag Italia s.r.l.",
number = "5 SUPPL. 1",

}

TY - JOUR

T1 - Efficacy of SH U 508 A (Levovist®) in color Doppler ultrasonography of hepatocellular carcinoma vascularization

AU - Angeli, E.

AU - Carpanelli, R.

AU - Crespi, G.

AU - Zanello, A.

AU - Sironi, S.

AU - Del Maschio, A.

PY - 1994

Y1 - 1994

N2 - To assess the efficacy of a new US contrast agent [SH U 508 A (Levovist®), Schering] in evaluating hepatocellular carcinoma (HCC) vascularization, 38 patients with 43 lesions were submitted to color Doppler US before and after i.v. contrast medium administration. Four patients were studied after arterial chemoembolization. The patients had been selected on the basis of suboptimal color Doppler signals on baseline images. Each patient received two to four injections of Levovist® in standard doses. Tumor vascularization was qualitatively graded on a 0-3 scale. Twelve tumors (27.9%) appeared avascular at baseline examinations, while 31 (72.1%) exhibited low to moderate flow signals. After contrast agent administration, color Doppler signals were markedly enhanced in 35/43 lesions (81.4%), lasting 40 to 240 seconds. The lack of enhancement was related to tumor hypovascularity (necrosis at CT), portal vein thrombosis, deep location and successful chemoembolization. The detection of flow signals in chemoembolized tumors was explained by the persistence of viable tumor tissue. After Levovist® administration, flow signals were detectable in 97.6% of the HCCs. Therefore, Levovist® proved to be an effective tool for color Doppler evaluation of HCC vascularization.

AB - To assess the efficacy of a new US contrast agent [SH U 508 A (Levovist®), Schering] in evaluating hepatocellular carcinoma (HCC) vascularization, 38 patients with 43 lesions were submitted to color Doppler US before and after i.v. contrast medium administration. Four patients were studied after arterial chemoembolization. The patients had been selected on the basis of suboptimal color Doppler signals on baseline images. Each patient received two to four injections of Levovist® in standard doses. Tumor vascularization was qualitatively graded on a 0-3 scale. Twelve tumors (27.9%) appeared avascular at baseline examinations, while 31 (72.1%) exhibited low to moderate flow signals. After contrast agent administration, color Doppler signals were markedly enhanced in 35/43 lesions (81.4%), lasting 40 to 240 seconds. The lack of enhancement was related to tumor hypovascularity (necrosis at CT), portal vein thrombosis, deep location and successful chemoembolization. The detection of flow signals in chemoembolized tumors was explained by the persistence of viable tumor tissue. After Levovist® administration, flow signals were detectable in 97.6% of the HCCs. Therefore, Levovist® proved to be an effective tool for color Doppler evaluation of HCC vascularization.

KW - HCC, Levovist®-enhanced color Doppler US

KW - liver HCC

UR - http://www.scopus.com/inward/record.url?scp=0028332409&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028332409&partnerID=8YFLogxK

M3 - Article

C2 - 8209014

AN - SCOPUS:0028332409

VL - 87

SP - 24

EP - 31

JO - Radiologia Medica

JF - Radiologia Medica

SN - 0033-8362

IS - 5 SUPPL. 1

ER -