Efficacy of silver coated surgical sutures on bacterial contamination, cellular response and wound healing

Anna Lucia Gallo, Federica Paladini, Alessandro Romano, Tiziano Verri, Angelo Quattrini, Alessandro Sannino, Mauro Pollini

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The resistance demonstrated by many microorganisms towards conventional antibiotics has stimulated the interest in alternative antimicrobial agents and in novel approaches for prevention of infections. Silver, a natural braod-spectrum antimicrobial agent known since antiquity, has been widely employed in biomedical field due to its recognized antibacterial, antifungal and antiviral properties. In this work, antibacterial silver coatings were deposited on absorbable surgical sutures through the in situ photo-chemical deposition of silver clusters. Scanning electron microscopy (SEM), Energy dispersive X-ray spectroscopy (EDX) and thermo-gravimetric analysis (TGA) were performed in order to investigate the presence and distribution of the silver clusters on the substrate. The amounts of silver deposited and released by the silver treated sutures were calculated through Inductively Coupled Plasma-Mass Spectroscopy (ICP-MS), and the results were related to the biodegradation of the material. The microbiological properties and the potential cytotoxicity of the silver-treated sutures were investigated in relation with hydrolysis experiments, in order to determine the effect of the degradation on antibacterial properties and biocompatibility.

Original languageEnglish
Pages (from-to)884-893
Number of pages10
JournalMaterials Science and Engineering C
Volume69
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

wound healing
healing
Silver
contamination
Contamination
silver
Antimicrobial agents
Anti-Infective Agents
antiquities
biodegradation
antibiotics
Inductively coupled plasma
biocompatibility
infectious diseases
Antibiotics
microorganisms
Cytotoxicity
Biodegradation
Biocompatibility
Microorganisms

Keywords

  • Biodegradation
  • Cytotoxicity
  • Infection
  • Silver
  • Suture

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

Cite this

Efficacy of silver coated surgical sutures on bacterial contamination, cellular response and wound healing. / Gallo, Anna Lucia; Paladini, Federica; Romano, Alessandro; Verri, Tiziano; Quattrini, Angelo; Sannino, Alessandro; Pollini, Mauro.

In: Materials Science and Engineering C, Vol. 69, 01.12.2016, p. 884-893.

Research output: Contribution to journalArticle

Gallo, Anna Lucia ; Paladini, Federica ; Romano, Alessandro ; Verri, Tiziano ; Quattrini, Angelo ; Sannino, Alessandro ; Pollini, Mauro. / Efficacy of silver coated surgical sutures on bacterial contamination, cellular response and wound healing. In: Materials Science and Engineering C. 2016 ; Vol. 69. pp. 884-893.
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