Efficacy of sofosbuvir and ledipasvir in an HCV+ gastro-resected patient

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1 Citation (Scopus)

Abstract

What is known and objective: The second-generation direct-acting antivirals represented the first major turning point for the eradication of HCV infection in almost all settings of patients. However, no data were available on use in gastro-resected patients. Case description: We report on a gastrectomized patient with chronic hepatitis C infection. She was treated with sofosbuvir and ledipasvir (SOF/LDV) for 12 weeks, with measurement of blood levels of the drugs. She obtained sustained virological response at week 12 and 24 without dose adjustment. What is new and conclusion: This case report can provide information useful for clinical practice in this set of patients and can open new perspectives in evaluating actual SOF/LDV bioavailability.

Original languageEnglish
Pages (from-to)621-623
Number of pages3
JournalJournal of Clinical Pharmacy and Therapeutics
Volume42
Issue number5
DOIs
Publication statusPublished - Oct 1 2017

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Chronic Hepatitis C
Infection
Biological Availability
Antiviral Agents
sofosbuvir drug combination ledipasvir
Pharmaceutical Preparations

Keywords

  • gastrectomy
  • hepatitis C virus
  • ledipasvir
  • pharmacokinetics
  • sofosbuvir

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

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abstract = "What is known and objective: The second-generation direct-acting antivirals represented the first major turning point for the eradication of HCV infection in almost all settings of patients. However, no data were available on use in gastro-resected patients. Case description: We report on a gastrectomized patient with chronic hepatitis C infection. She was treated with sofosbuvir and ledipasvir (SOF/LDV) for 12 weeks, with measurement of blood levels of the drugs. She obtained sustained virological response at week 12 and 24 without dose adjustment. What is new and conclusion: This case report can provide information useful for clinical practice in this set of patients and can open new perspectives in evaluating actual SOF/LDV bioavailability.",
keywords = "gastrectomy, hepatitis C virus, ledipasvir, pharmacokinetics, sofosbuvir",
author = "C. Taibi and M. Tempestilli and A. D'Avolio and Garbuglia, {A. R.} and {De Nicol{\`o}}, A. and M. Montalbano and G. D'Offizi",
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T1 - Efficacy of sofosbuvir and ledipasvir in an HCV+ gastro-resected patient

AU - Taibi, C.

AU - Tempestilli, M.

AU - D'Avolio, A.

AU - Garbuglia, A. R.

AU - De Nicolò, A.

AU - Montalbano, M.

AU - D'Offizi, G.

PY - 2017/10/1

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N2 - What is known and objective: The second-generation direct-acting antivirals represented the first major turning point for the eradication of HCV infection in almost all settings of patients. However, no data were available on use in gastro-resected patients. Case description: We report on a gastrectomized patient with chronic hepatitis C infection. She was treated with sofosbuvir and ledipasvir (SOF/LDV) for 12 weeks, with measurement of blood levels of the drugs. She obtained sustained virological response at week 12 and 24 without dose adjustment. What is new and conclusion: This case report can provide information useful for clinical practice in this set of patients and can open new perspectives in evaluating actual SOF/LDV bioavailability.

AB - What is known and objective: The second-generation direct-acting antivirals represented the first major turning point for the eradication of HCV infection in almost all settings of patients. However, no data were available on use in gastro-resected patients. Case description: We report on a gastrectomized patient with chronic hepatitis C infection. She was treated with sofosbuvir and ledipasvir (SOF/LDV) for 12 weeks, with measurement of blood levels of the drugs. She obtained sustained virological response at week 12 and 24 without dose adjustment. What is new and conclusion: This case report can provide information useful for clinical practice in this set of patients and can open new perspectives in evaluating actual SOF/LDV bioavailability.

KW - gastrectomy

KW - hepatitis C virus

KW - ledipasvir

KW - pharmacokinetics

KW - sofosbuvir

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