Efficacy of Sofosbuvir/Ledipasvir in Adolescents With Chronic Hepatitis C Genotypes 1, 3, and 4: A Real-world Study

Daniele Serranti; Gabriella Nebbia; Mara Cananzi; Emanuele Nicastro; Fabiola Di Dato; Federica Nuti; Silvia Garazzino; Erika Silvestro; Vania Giacomet; Federica Forlanini; Michele Pinon; Pier Luigi Calvo; Silvia Riva; Icilio Dodi; Antonina Marta Cangelosi; Roberto Antonucci; Silvia Ricci; Elisa Bartolini; Greta Mastrangelo; Sandra Trapani; Matteo Lenge; Paola Gaio; Pietro Vajro; Raffaele Iorio; Lorenzo D'Antiga; Giuseppe Indolfi

doi:10.1097/MPG.0000000000002900

Efficacy of Sofosbuvir/Ledipasvir in Adolescents With Chronic Hepatitis C Genotypes 1, 3, and 4: A Real-world Study

Daniele Serranti, Gabriella Nebbia, Mara Cananzi, Emanuele Nicastro, Fabiola Di Dato, Federica Nuti, Silvia Garazzino, Erika Silvestro, Vania Giacomet, Federica Forlanini, Michele Pinon, Pier Luigi Calvo, Silvia Riva, Icilio Dodi, Antonina Marta Cangelosi, Roberto Antonucci, Silvia Ricci, Elisa Bartolini, Greta Mastrangelo, Sandra TrapaniMatteo Lenge, Paola Gaio, Pietro Vajro, Raffaele Iorio, Lorenzo D'Antiga, Giuseppe Indolfi

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: Sofosbuvir/Ledipasvir (SOF/LDV) has been approved by the European Medicine Agency (EMA) for the treatment of children and adolescents (at least 3 years of age) with chronic hepatitis C (CHC) genotype 1, 3, and 4 infection. The aim of this study was to evaluate the efficacy and safety of SOF/LDV in adolescents (12 to

Original language	English
Pages (from-to)	95-100
Number of pages	6
Journal	Journal of Pediatric Gastroenterology and Nutrition
Volume	72
Issue number	1
DOIs	https://doi.org/10.1097/MPG.0000000000002900
Publication status	Accepted/In press - Jul 29 2020

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Serranti, D., Nebbia, G., Cananzi, M., Nicastro, E., Di Dato, F., Nuti, F., Garazzino, S., Silvestro, E., Giacomet, V., Forlanini, F., Pinon, M., Calvo, P. L., Riva, S., Dodi, I., Cangelosi, A. M., Antonucci, R., Ricci, S., Bartolini, E., Mastrangelo, G., ... Indolfi, G. (Accepted/In press). Efficacy of Sofosbuvir/Ledipasvir in Adolescents With Chronic Hepatitis C Genotypes 1, 3, and 4: A Real-world Study. Journal of Pediatric Gastroenterology and Nutrition, 72(1), 95-100. https://doi.org/10.1097/MPG.0000000000002900

Efficacy of Sofosbuvir/Ledipasvir in Adolescents With Chronic Hepatitis C Genotypes 1, 3, and 4 : A Real-world Study. / Serranti, Daniele; Nebbia, Gabriella; Cananzi, Mara; Nicastro, Emanuele; Di Dato, Fabiola; Nuti, Federica; Garazzino, Silvia; Silvestro, Erika; Giacomet, Vania; Forlanini, Federica; Pinon, Michele; Calvo, Pier Luigi; Riva, Silvia; Dodi, Icilio; Cangelosi, Antonina Marta; Antonucci, Roberto; Ricci, Silvia; Bartolini, Elisa; Mastrangelo, Greta; Trapani, Sandra; Lenge, Matteo; Gaio, Paola; Vajro, Pietro; Iorio, Raffaele; D'Antiga, Lorenzo; Indolfi, Giuseppe.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 72, No. 1, 29.07.2020, p. 95-100.

Research output: Contribution to journal › Article › peer-review

Serranti, D, Nebbia, G, Cananzi, M, Nicastro, E, Di Dato, F, Nuti, F, Garazzino, S, Silvestro, E, Giacomet, V, Forlanini, F, Pinon, M, Calvo, PL, Riva, S, Dodi, I, Cangelosi, AM, Antonucci, R, Ricci, S, Bartolini, E, Mastrangelo, G, Trapani, S, Lenge, M, Gaio, P, Vajro, P, Iorio, R, D'Antiga, L & Indolfi, G 2020, 'Efficacy of Sofosbuvir/Ledipasvir in Adolescents With Chronic Hepatitis C Genotypes 1, 3, and 4: A Real-world Study', Journal of Pediatric Gastroenterology and Nutrition, vol. 72, no. 1, pp. 95-100. https://doi.org/10.1097/MPG.0000000000002900

Serranti, Daniele ; Nebbia, Gabriella ; Cananzi, Mara ; Nicastro, Emanuele ; Di Dato, Fabiola ; Nuti, Federica ; Garazzino, Silvia ; Silvestro, Erika ; Giacomet, Vania ; Forlanini, Federica ; Pinon, Michele ; Calvo, Pier Luigi ; Riva, Silvia ; Dodi, Icilio ; Cangelosi, Antonina Marta ; Antonucci, Roberto ; Ricci, Silvia ; Bartolini, Elisa ; Mastrangelo, Greta ; Trapani, Sandra ; Lenge, Matteo ; Gaio, Paola ; Vajro, Pietro ; Iorio, Raffaele ; D'Antiga, Lorenzo ; Indolfi, Giuseppe. / Efficacy of Sofosbuvir/Ledipasvir in Adolescents With Chronic Hepatitis C Genotypes 1, 3, and 4 : A Real-world Study. In: Journal of Pediatric Gastroenterology and Nutrition. 2020 ; Vol. 72, No. 1. pp. 95-100.

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abstract = "OBJECTIVES: Sofosbuvir/Ledipasvir (SOF/LDV) has been approved by the European Medicine Agency (EMA) for the treatment of children and adolescents (at least 3 years of age) with chronic hepatitis C (CHC) genotype 1, 3, and 4 infection. The aim of this study was to evaluate the efficacy and safety of SOF/LDV in adolescents (12 to ",

author = "Daniele Serranti and Gabriella Nebbia and Mara Cananzi and Emanuele Nicastro and {Di Dato}, Fabiola and Federica Nuti and Silvia Garazzino and Erika Silvestro and Vania Giacomet and Federica Forlanini and Michele Pinon and Calvo, {Pier Luigi} and Silvia Riva and Icilio Dodi and Cangelosi, {Antonina Marta} and Roberto Antonucci and Silvia Ricci and Elisa Bartolini and Greta Mastrangelo and Sandra Trapani and Matteo Lenge and Paola Gaio and Pietro Vajro and Raffaele Iorio and Lorenzo D'Antiga and Giuseppe Indolfi",

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AU - Serranti, Daniele

AU - Nebbia, Gabriella

AU - Cananzi, Mara

AU - Nicastro, Emanuele

AU - Di Dato, Fabiola

AU - Nuti, Federica

AU - Garazzino, Silvia

AU - Silvestro, Erika

AU - Giacomet, Vania

AU - Forlanini, Federica

AU - Pinon, Michele

AU - Calvo, Pier Luigi

AU - Riva, Silvia

AU - Dodi, Icilio

AU - Cangelosi, Antonina Marta

AU - Antonucci, Roberto

AU - Ricci, Silvia

AU - Bartolini, Elisa

AU - Mastrangelo, Greta

AU - Trapani, Sandra

AU - Lenge, Matteo

AU - Gaio, Paola

AU - Vajro, Pietro

AU - Iorio, Raffaele

AU - D'Antiga, Lorenzo

AU - Indolfi, Giuseppe

N1 - Publisher Copyright: Copyright © 2020 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

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