Efficacy of sorafenib and impact on cardiac function in patients with thyroid cancer: A retrospective analysis

L. Mortara, G. Pera, E. Monti, S. Morbelli, F. Minuto, G. Sambuceti, M. Giusti

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Sorafenib has recently been recognized as an important standard option for the management of patients with differentiated thyroid cancer. Although data concerning cardiac safety are available in pan-tumor studies, no data are available on its use in everyday clinical practice in patients with thyroid cancer. Methods: In the off-label program of our institution, we enrolled 14 patients with different histological types of thyroid cancer suitable for treatment with sorafenib. Our aims were to evaluate cardiac safety factors - LVEF (left ventricular ejection fraction), heart rate and blood pressure - the cardiac markers NT-proBNP and troponin I, radiological response evaluated by CT and 18FDG-PET (according to RECIST 1.1 criteria) and biomarker reduction (Eastern Cooperative Oncology Group Performance Status: ECOG PS) 0-2. Results: Patients with ECOG PS 2 accounted for 36 %. After starting sorafenib, many patients displayed reduced or stabilized metabolic activity in target lesions (clinical benefit = 44 %), radiologic reduction or stabilization (74 %) and decreased cancer markers (90 %). Lung metastases displayed the largest reductions in size. Median overall survival (OS) was 7 months and median progression-free survival (PFS) was 3 months. No sign of cardiotoxicity was observed in almost all patients. LVEF was altered in two patients and proved symptomatic in one. Conclusions: Sorafenib seems to be effective in reducing disease progression in the early stages of treatment (3-6 months). Responses varied considerably according to the criteria investigated. Cardiac toxicities did not raise concerns and were in line with data reported in other malignancies. However, cardiac monitoring is recommended.

Original languageEnglish
Pages (from-to)1099-1108
Number of pages10
JournalAcademic Psychiatry
Volume37
Issue number11
DOIs
Publication statusPublished - Oct 24 2014

Keywords

  • Calcitonin
  • Cardiotoxicity
  • Sorafenib
  • Thyroglobulin
  • Thyroid cancer

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Education

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