Efficacy of sulforaphane in neurodegenerative diseases

Giovanni Schepici, Placido Bramanti, Emanuela Mazzon

Research output: Contribution to journalReview articlepeer-review


Sulforaphane (SFN) is a phytocompound belonging to the isothiocyanate family. Although it was also found in seeds and mature plants, SFN is mainly present in sprouts of many cruciferous vegetables, including cabbage, broccoli, cauliflower, and Brussels sprouts. SFN is produced by the conversion of glucoraphanin through the enzyme myrosinase, which leads to the formation of this isothiocyanate. SFN is especially characterized by antioxidant, anti-inflammatory, and anti-apoptotic properties, and for this reason, it aroused the interest of researchers. The aim of this review is to summarize the experimental studies present on Pubmed that report the efficacy of SFN in the treatment of neurodegenerative disease, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). Therefore, thanks to its beneficial effects, SFN could be useful as a supplement to counteracting neurodegenerative diseases.

Original languageEnglish
Article number8637
Pages (from-to)1-26
Number of pages26
JournalInternational Journal of Molecular Sciences
Issue number22
Publication statusPublished - Nov 2 2020


  • Alzheimer’s disease
  • Multiple sclerosis
  • Neuroprotective effects
  • Parkinson’s disease
  • Sulforaphane

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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