Efficacy of temporary positive expiratory pressure (TPEP) in patients with lung diseases and chronic mucus hypersecretion. the UNIKO® project: A multicentre randomized controlled trial

Elena Venturelli, Ernesto Crisafulli, Assunta Debiase, Daniela Righi, Daniele Berrighi, Pier Paolo Cavicchioli, Guido Vagheggini, Francesco Dabrosca, Bruno Balbi, Mara Paneroni, Luca Bianchi, Michele Vitacca, Vittoria Galimberti, Michele Zaurino, Giorgio Schiavoni, Andrea Iattoni, Nicolino Ambrosino, Enrico M. Clini

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate whether temporary positive expiratory pressure provides benefit in patients with lung diseases and chronic hypersecretion. Design: Single blind multicentre randomized trial. Setting: Five Italian rehabilitation centres. Participants: Ninety-eight patients with chronic obstructive pulmonary disease and/or chronic bronchitis (n=78), or bronchiectasis (n=20), with a peak cough expiratory flow >150 l/min and sputum production >30 ml/day, randomly included into two treatment groups. Interventions: For 10 consecutive days, the active group performed twice a day 20-minute cycles of manually assisted breathing techniques in sequence with the addition of 15 minutes of temporary positive expiratory pressure, while the control group was treated by manually assisted breathing techniques alone. Measures: Within and between group changes of arterial oxygenation index, lung volumes and respiratory muscles strength were recorded at enrolment and after 3 and 10 treatment sessions. Pre-to-post treatment change of sputum volume and bronchial encumbrance (Ä-visual analog scale), sputum density and purulence were compared daily within the study period. Results: No significant changes were recorded for the oxygenation index, while dynamic lung volumes and respiratory muscle strength significantly (P

Original languageEnglish
Pages (from-to)336-346
Number of pages11
JournalClinical Rehabilitation
Volume27
Issue number4
DOIs
Publication statusPublished - Apr 2013

Keywords

  • bronchial drainage
  • cough
  • Hypersecretion
  • rehabilitation
  • temporary positive expiratory pressure

ASJC Scopus subject areas

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation

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    Venturelli, E., Crisafulli, E., Debiase, A., Righi, D., Berrighi, D., Cavicchioli, P. P., Vagheggini, G., Dabrosca, F., Balbi, B., Paneroni, M., Bianchi, L., Vitacca, M., Galimberti, V., Zaurino, M., Schiavoni, G., Iattoni, A., Ambrosino, N., & Clini, E. M. (2013). Efficacy of temporary positive expiratory pressure (TPEP) in patients with lung diseases and chronic mucus hypersecretion. the UNIKO® project: A multicentre randomized controlled trial. Clinical Rehabilitation, 27(4), 336-346. https://doi.org/10.1177/0269215512458940