Efficacy of the association of 13-cis-retinoic acid (13cRA) and alpha-interferon 2a (α-IFN 2a) in moderate-severe cervical intraepithelial neoplasia (CIN II-III): A pilot study

Salvatore Toma, Nicola Ragni, Patrizia Raffo, Fausto Boselli, Claudio Gustavino, Sergio Rugiati, Franco Formelli, Raffaella Palumbo, Riccardo Rosso, Luigi De Cecco

Research output: Contribution to journalArticlepeer-review

Abstract

Recent in vitro studies have suggested a possible therapeutic synergism between α-IFN 2a and 13cRA in certain neoplasias, while encouraging in vivo findings strongly support the enhanced effectiveness of the two agents when used in combination. The specific aim of our study was to evaluate the efficacy and the toxicity of the association of 13cRA and α-IFN 2a in patients with CIN II and CIN III who refused surgical treatment. Twenty-one patients (aged between 25 and 58 years), of which 14 were CIN II and 7 CIN III, entered the study. 13cRA (orally at 0.5-1 mg/Kg/day) and α-IFN 2a (intramuscular at 3 x 106 I.U./day for the first 15 days, then 3 times/week for the following four weeks) were administered simultaneously for eight consecutive weeks. 13/21 (62%) histologically verified objective responses (6 complete and 7 partial) were achieved. We also obtained 8 stable diseases. Compliance was generally good and no delays in therapy due to toxicity were recorded (except for two patients presenting WHO degree III cutaneous and mucosal toxicity which regressed one week after suspending treatment). Human Papilloma Virus (HPV) was initially detected in 16/21 (76%) patients, while HPV negativization after treatment was observed in 3/16 (19%). Although preliminary and requiring long-term assessment, the encouraging results of this study confirm the need for further investigation on the role of systemic medical therapy in the treatment of CINs.

Original languageEnglish
Pages (from-to)931-936
Number of pages6
JournalAnticancer Research
Volume16
Issue number2
Publication statusPublished - 1996

Keywords

  • α-Interferon 2a
  • 13-cis-retinoic acid
  • Cervical intraepithelial neoplasia

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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