Efficacy of thermal ablation in benign non-functioning solid thyroid nodule

A systematic review and meta-analysis

Pierpaolo Trimboli, Marco Castellana, Luca Maria Sconfienza, Camilla Virili, Lorenzo Carlo Pescatori, Roberto Cesareo, Francesco Giorgino, Roberto Negro, Luca Giovanella, Giovanni Mauri

Research output: Contribution to journalArticle

Abstract

Background: Image-guided thermal ablations are commonly used in the treatment of thyroid nodules. Radiofrequency ablation (RFA) and laser ablation are the most commonly used. Here we aimed to obtain solid evidence of the long-term efficacy of RFA and laser ablation in benign non-functioning solid thyroid nodules (BNFSTN). Methods: PubMed, CENTRAL, Scopus, and Web of Science were searched until March 2019. Studies reporting the effectiveness of RFA or laser ablation in patients with BNFSTN in terms of volume reduction rate (VRR), compressive symptoms and cosmetic concerns were included. Complications were also assessed. Results: Out of 963 papers, 12 studies on RFA and 12 on laser ablation were included, assessing 1186 and 2009 BNFSTNs, respectively. Overall, VRR at 6, 12, 24, and 36 months was 60%, 66%, 62%, and 53%. VRR of RFA was 68%, 75%, and 87%, respectively. VRR of laser ablation was 48%, 52%, 45%, and 44%, respectively. Baseline volume of nodules undergone RFA was significantly smaller compared to laser ablation (20.1 ± 22.4 versus 24.6 ± 23.6 ml; p < 0.01). Nodules smaller than 30 ml obtained better outcomes than larger ones. A significant reduction in compressive symptoms and cosmetic concerns was found after RFA. Conclusions: This meta-analysis showed that both RFA and laser ablation are able to obtain a significant volume reduction in BNFSTNs. A significant volume reduction is already evident at 6 months after thermal ablation and results are stable over the time.

Original languageEnglish
JournalEndocrine
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Thyroid Nodule
Laser Therapy
Meta-Analysis
Hot Temperature
Cosmetics
PubMed

Keywords

  • Laser ablation
  • Meta-analysis
  • Non-functioning thyroid nodules
  • Radiofrequency ablation
  • Volume reduction rate

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Efficacy of thermal ablation in benign non-functioning solid thyroid nodule : A systematic review and meta-analysis. / Trimboli, Pierpaolo; Castellana, Marco; Sconfienza, Luca Maria; Virili, Camilla; Pescatori, Lorenzo Carlo; Cesareo, Roberto; Giorgino, Francesco; Negro, Roberto; Giovanella, Luca; Mauri, Giovanni.

In: Endocrine, 01.01.2019.

Research output: Contribution to journalArticle

Trimboli, Pierpaolo ; Castellana, Marco ; Sconfienza, Luca Maria ; Virili, Camilla ; Pescatori, Lorenzo Carlo ; Cesareo, Roberto ; Giorgino, Francesco ; Negro, Roberto ; Giovanella, Luca ; Mauri, Giovanni. / Efficacy of thermal ablation in benign non-functioning solid thyroid nodule : A systematic review and meta-analysis. In: Endocrine. 2019.
@article{7bab23e682574f64804e437768995c7d,
title = "Efficacy of thermal ablation in benign non-functioning solid thyroid nodule: A systematic review and meta-analysis",
abstract = "Background: Image-guided thermal ablations are commonly used in the treatment of thyroid nodules. Radiofrequency ablation (RFA) and laser ablation are the most commonly used. Here we aimed to obtain solid evidence of the long-term efficacy of RFA and laser ablation in benign non-functioning solid thyroid nodules (BNFSTN). Methods: PubMed, CENTRAL, Scopus, and Web of Science were searched until March 2019. Studies reporting the effectiveness of RFA or laser ablation in patients with BNFSTN in terms of volume reduction rate (VRR), compressive symptoms and cosmetic concerns were included. Complications were also assessed. Results: Out of 963 papers, 12 studies on RFA and 12 on laser ablation were included, assessing 1186 and 2009 BNFSTNs, respectively. Overall, VRR at 6, 12, 24, and 36 months was 60{\%}, 66{\%}, 62{\%}, and 53{\%}. VRR of RFA was 68{\%}, 75{\%}, and 87{\%}, respectively. VRR of laser ablation was 48{\%}, 52{\%}, 45{\%}, and 44{\%}, respectively. Baseline volume of nodules undergone RFA was significantly smaller compared to laser ablation (20.1 ± 22.4 versus 24.6 ± 23.6 ml; p < 0.01). Nodules smaller than 30 ml obtained better outcomes than larger ones. A significant reduction in compressive symptoms and cosmetic concerns was found after RFA. Conclusions: This meta-analysis showed that both RFA and laser ablation are able to obtain a significant volume reduction in BNFSTNs. A significant volume reduction is already evident at 6 months after thermal ablation and results are stable over the time.",
keywords = "Laser ablation, Meta-analysis, Non-functioning thyroid nodules, Radiofrequency ablation, Volume reduction rate",
author = "Pierpaolo Trimboli and Marco Castellana and Sconfienza, {Luca Maria} and Camilla Virili and Pescatori, {Lorenzo Carlo} and Roberto Cesareo and Francesco Giorgino and Roberto Negro and Luca Giovanella and Giovanni Mauri",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s12020-019-02019-3",
language = "English",
journal = "Endocrine",
issn = "1355-008X",
publisher = "Humana Press Inc.",

}

TY - JOUR

T1 - Efficacy of thermal ablation in benign non-functioning solid thyroid nodule

T2 - A systematic review and meta-analysis

AU - Trimboli, Pierpaolo

AU - Castellana, Marco

AU - Sconfienza, Luca Maria

AU - Virili, Camilla

AU - Pescatori, Lorenzo Carlo

AU - Cesareo, Roberto

AU - Giorgino, Francesco

AU - Negro, Roberto

AU - Giovanella, Luca

AU - Mauri, Giovanni

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Image-guided thermal ablations are commonly used in the treatment of thyroid nodules. Radiofrequency ablation (RFA) and laser ablation are the most commonly used. Here we aimed to obtain solid evidence of the long-term efficacy of RFA and laser ablation in benign non-functioning solid thyroid nodules (BNFSTN). Methods: PubMed, CENTRAL, Scopus, and Web of Science were searched until March 2019. Studies reporting the effectiveness of RFA or laser ablation in patients with BNFSTN in terms of volume reduction rate (VRR), compressive symptoms and cosmetic concerns were included. Complications were also assessed. Results: Out of 963 papers, 12 studies on RFA and 12 on laser ablation were included, assessing 1186 and 2009 BNFSTNs, respectively. Overall, VRR at 6, 12, 24, and 36 months was 60%, 66%, 62%, and 53%. VRR of RFA was 68%, 75%, and 87%, respectively. VRR of laser ablation was 48%, 52%, 45%, and 44%, respectively. Baseline volume of nodules undergone RFA was significantly smaller compared to laser ablation (20.1 ± 22.4 versus 24.6 ± 23.6 ml; p < 0.01). Nodules smaller than 30 ml obtained better outcomes than larger ones. A significant reduction in compressive symptoms and cosmetic concerns was found after RFA. Conclusions: This meta-analysis showed that both RFA and laser ablation are able to obtain a significant volume reduction in BNFSTNs. A significant volume reduction is already evident at 6 months after thermal ablation and results are stable over the time.

AB - Background: Image-guided thermal ablations are commonly used in the treatment of thyroid nodules. Radiofrequency ablation (RFA) and laser ablation are the most commonly used. Here we aimed to obtain solid evidence of the long-term efficacy of RFA and laser ablation in benign non-functioning solid thyroid nodules (BNFSTN). Methods: PubMed, CENTRAL, Scopus, and Web of Science were searched until March 2019. Studies reporting the effectiveness of RFA or laser ablation in patients with BNFSTN in terms of volume reduction rate (VRR), compressive symptoms and cosmetic concerns were included. Complications were also assessed. Results: Out of 963 papers, 12 studies on RFA and 12 on laser ablation were included, assessing 1186 and 2009 BNFSTNs, respectively. Overall, VRR at 6, 12, 24, and 36 months was 60%, 66%, 62%, and 53%. VRR of RFA was 68%, 75%, and 87%, respectively. VRR of laser ablation was 48%, 52%, 45%, and 44%, respectively. Baseline volume of nodules undergone RFA was significantly smaller compared to laser ablation (20.1 ± 22.4 versus 24.6 ± 23.6 ml; p < 0.01). Nodules smaller than 30 ml obtained better outcomes than larger ones. A significant reduction in compressive symptoms and cosmetic concerns was found after RFA. Conclusions: This meta-analysis showed that both RFA and laser ablation are able to obtain a significant volume reduction in BNFSTNs. A significant volume reduction is already evident at 6 months after thermal ablation and results are stable over the time.

KW - Laser ablation

KW - Meta-analysis

KW - Non-functioning thyroid nodules

KW - Radiofrequency ablation

KW - Volume reduction rate

UR - http://www.scopus.com/inward/record.url?scp=85069532502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069532502&partnerID=8YFLogxK

U2 - 10.1007/s12020-019-02019-3

DO - 10.1007/s12020-019-02019-3

M3 - Article

JO - Endocrine

JF - Endocrine

SN - 1355-008X

ER -