Efficacy of TIAGIN® on post-operative reepithelialization in women subjected to cervical surgery (LEEP or laser cone biopsies): Case-control study

Anna Daniela Iacobone, Eleonora Petra Preti, Ailyn Mariela Vidal Urbinati, Eugenia Tomás Roldán

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: to evaluate the efficacy of post-operative treatment with TIAGIN® vaginal softgel in the reepithelialisation of the cervix and the prevention of the most common post-operative complications. Methods: a prospective and randomised case-control study in women who had undergone cervical surgery: TIAGIN® users for 15 days and non-users. All patients underwent a clinical examination at baseline and at 30 days. The post-treatment reepithelialisation process was evaluated by 2 colposcopists. A visual analogue questionnaire was completed in the second and fourth week after surgery to assess vaginal bleeding, leucorrhoea, abdominal pain and impact of pain on quality of life. Results: 30 patients were enrolled: 12 as controls and 18 as cases. 5 LEEP (41.77%) and 7 laser cone biopsies (58.33%) were carried out among controls and 9 LEEP (50.00%) and 9 laser cone biopsies (50.00%) among cases. CIN2-3 was detected in more than 70% of patients. No statistically significant differences were observed in post-operative complications, with the exception of the rate of atypical leucorrhoea (66.67% in controls vs 16.67% in cases) (p=0.011). Complete reepithelialisation was seen in 66.6% of cases and in 8.33% of controls, respectively (p=0.002). Conclusion: the post-operative use of TIAGIN® vaginal softgel leads to rapid cerval reepithelialisation.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalItalian Journal of Gynaecology and Obstetrics
Volume29
DOIs
Publication statusPublished - Mar 1 2017

Keywords

  • Cervical surgery
  • Post-operative complications
  • Reepithelialisation
  • TIAGIN® vaginal softgel

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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