TY - JOUR
T1 - Efficacy of tolterodine in women with detrusor overactivity and anterior vaginal wall prolapse
T2 - Is it the same?
AU - Salvatore, S.
AU - Serati, M.
AU - Ghezzi, F.
AU - Uccella, S.
AU - Cromi, A.
AU - Bolis, P.
PY - 2007/11
Y1 - 2007/11
N2 - The aim of this study was to assess the efficacy of tolterodine in women with overactive bladder (OAB) and concomitant anterior vaginal prolapse. In this prospective study, 235 consecutive women with OAB symptoms and urodynamic diagnosis of detrusor overactivity who either had no prolapse or had pure anterior vaginal prolapse were included: 184 women (group 1) had no prolapse and 51 women (group 2) had anterior prolapse greater than and equal to stage IIa. Tolterodine 4 mg slow release once a day was prescribed. After 12 weeks, women were reassessed using a 3-point scale (no change, improvement and cured). A total of 158 (85.9%) women in group 1 and 31 (60.8%) women in group 2 reported improvement or cure (P = 0.0002). Women with OAB and significant anterior vaginal prolapse should be informed of a reduced efficacy of antimuscarinics in treating their urinary symptoms.
AB - The aim of this study was to assess the efficacy of tolterodine in women with overactive bladder (OAB) and concomitant anterior vaginal prolapse. In this prospective study, 235 consecutive women with OAB symptoms and urodynamic diagnosis of detrusor overactivity who either had no prolapse or had pure anterior vaginal prolapse were included: 184 women (group 1) had no prolapse and 51 women (group 2) had anterior prolapse greater than and equal to stage IIa. Tolterodine 4 mg slow release once a day was prescribed. After 12 weeks, women were reassessed using a 3-point scale (no change, improvement and cured). A total of 158 (85.9%) women in group 1 and 31 (60.8%) women in group 2 reported improvement or cure (P = 0.0002). Women with OAB and significant anterior vaginal prolapse should be informed of a reduced efficacy of antimuscarinics in treating their urinary symptoms.
KW - Anterior vaginal prolapse
KW - Antimuscarinics
KW - Detrusor overactivity
KW - Overactive bladder
KW - Tolterodine
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U2 - 10.1111/j.1471-0528.2007.01399.x
DO - 10.1111/j.1471-0528.2007.01399.x
M3 - Article
C2 - 17877779
AN - SCOPUS:35349011056
VL - 114
SP - 1436
EP - 1438
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
SN - 1470-0328
IS - 11
ER -