Efficacy of tolterodine in women with detrusor overactivity and anterior vaginal wall prolapse: Is it the same?

S. Salvatore, M. Serati, F. Ghezzi, S. Uccella, A. Cromi, P. Bolis

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to assess the efficacy of tolterodine in women with overactive bladder (OAB) and concomitant anterior vaginal prolapse. In this prospective study, 235 consecutive women with OAB symptoms and urodynamic diagnosis of detrusor overactivity who either had no prolapse or had pure anterior vaginal prolapse were included: 184 women (group 1) had no prolapse and 51 women (group 2) had anterior prolapse greater than and equal to stage IIa. Tolterodine 4 mg slow release once a day was prescribed. After 12 weeks, women were reassessed using a 3-point scale (no change, improvement and cured). A total of 158 (85.9%) women in group 1 and 31 (60.8%) women in group 2 reported improvement or cure (P = 0.0002). Women with OAB and significant anterior vaginal prolapse should be informed of a reduced efficacy of antimuscarinics in treating their urinary symptoms.

Original languageEnglish
Pages (from-to)1436-1438
Number of pages3
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume114
Issue number11
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Anterior vaginal prolapse
  • Antimuscarinics
  • Detrusor overactivity
  • Overactive bladder
  • Tolterodine

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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