Abstract
From 2000 to 2004, 152 patients with multiple myeloma aged ≤65 years, enrolled in high-dose programs, were treated with two schedules of DCEP (dexamethasone, cyclophosphamide, etoposide, and cisplatin): 106 patients (group I) were mobilized with the infusional version of DCEP (infusional-DCEP), and 46 patients (group II) with a shorter version (DCEP-short). The median number of CD34+ cells collected was similar in the two groups as was the percentage of patients yielding ≥4 × 106cells/kg. The proportion of patients in whom mobilization failed was similar in the two groups. The incidence of WHO grade III neutropenia was higher in group II, although the difference was not statistically significant; the percentage of patients requiring hospitalization for severe infections was similar in the two groups. The incidence of WHO grade IV thrombocytopenia did not differ between the two groups. The response rate was 72% in group I and 80% in group II with similar percentages of patients achieving good responses. DCEP-short is a good mobilizing regimen, sharing the same characteristics as infusional-DCEP: high mobilizing efficacy, low toxicity and good antitumor activity. This new schedule of DCEP does, however, allow complete outpatient management and so could be advantageously included in any high-dose therapy program.
| Original language | English |
|---|---|
| Pages (from-to) | 951-954 |
| Number of pages | 4 |
| Journal | Bone Marrow Transplantation |
| Volume | 36 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Dec 2005 |
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Keywords
- Chemotherapy
- DCEP
- Mobilization
- Peripheral stem cells
ASJC Scopus subject areas
- Hematology
- Transplantation
Cite this
Efficacy, toxicity and feasibility of a shorter schedule of DCEP regimen for stem cell mobilization in multiple myeloma. / Corso, A.; Mangiacavalli, S.; Nosari, A.; Castagnola, C.; Zappasodi, P.; Cafro, A. M.; Astori, C.; Bonfichi, M.; Varettoni, M.; Rusconi, C.; Troletti, D.; Pascutto, C.; Morra, E.; Lazzarino, M.
In: Bone Marrow Transplantation, Vol. 36, No. 11, 12.2005, p. 951-954.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficacy, toxicity and feasibility of a shorter schedule of DCEP regimen for stem cell mobilization in multiple myeloma
AU - Corso, A.
AU - Mangiacavalli, S.
AU - Nosari, A.
AU - Castagnola, C.
AU - Zappasodi, P.
AU - Cafro, A. M.
AU - Astori, C.
AU - Bonfichi, M.
AU - Varettoni, M.
AU - Rusconi, C.
AU - Troletti, D.
AU - Pascutto, C.
AU - Morra, E.
AU - Lazzarino, M.
PY - 2005/12
Y1 - 2005/12
N2 - From 2000 to 2004, 152 patients with multiple myeloma aged ≤65 years, enrolled in high-dose programs, were treated with two schedules of DCEP (dexamethasone, cyclophosphamide, etoposide, and cisplatin): 106 patients (group I) were mobilized with the infusional version of DCEP (infusional-DCEP), and 46 patients (group II) with a shorter version (DCEP-short). The median number of CD34+ cells collected was similar in the two groups as was the percentage of patients yielding ≥4 × 106cells/kg. The proportion of patients in whom mobilization failed was similar in the two groups. The incidence of WHO grade III neutropenia was higher in group II, although the difference was not statistically significant; the percentage of patients requiring hospitalization for severe infections was similar in the two groups. The incidence of WHO grade IV thrombocytopenia did not differ between the two groups. The response rate was 72% in group I and 80% in group II with similar percentages of patients achieving good responses. DCEP-short is a good mobilizing regimen, sharing the same characteristics as infusional-DCEP: high mobilizing efficacy, low toxicity and good antitumor activity. This new schedule of DCEP does, however, allow complete outpatient management and so could be advantageously included in any high-dose therapy program.
AB - From 2000 to 2004, 152 patients with multiple myeloma aged ≤65 years, enrolled in high-dose programs, were treated with two schedules of DCEP (dexamethasone, cyclophosphamide, etoposide, and cisplatin): 106 patients (group I) were mobilized with the infusional version of DCEP (infusional-DCEP), and 46 patients (group II) with a shorter version (DCEP-short). The median number of CD34+ cells collected was similar in the two groups as was the percentage of patients yielding ≥4 × 106cells/kg. The proportion of patients in whom mobilization failed was similar in the two groups. The incidence of WHO grade III neutropenia was higher in group II, although the difference was not statistically significant; the percentage of patients requiring hospitalization for severe infections was similar in the two groups. The incidence of WHO grade IV thrombocytopenia did not differ between the two groups. The response rate was 72% in group I and 80% in group II with similar percentages of patients achieving good responses. DCEP-short is a good mobilizing regimen, sharing the same characteristics as infusional-DCEP: high mobilizing efficacy, low toxicity and good antitumor activity. This new schedule of DCEP does, however, allow complete outpatient management and so could be advantageously included in any high-dose therapy program.
KW - Chemotherapy
KW - DCEP
KW - Mobilization
KW - Peripheral stem cells
UR - http://www.scopus.com/inward/record.url?scp=28544442682&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28544442682&partnerID=8YFLogxK
U2 - 10.1038/sj.bmt.1705166
DO - 10.1038/sj.bmt.1705166
M3 - Article
C2 - 16184179
AN - SCOPUS:28544442682
VL - 36
SP - 951
EP - 954
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
SN - 0268-3369
IS - 11
ER -