Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures

Giulia Menchinelli, Flora Marzia Liotti, Liliana Giordano, Giulia De Angelis, Maurizio Sanguinetti, Teresa Spanu, Brunella Posteraro

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed the antimicrobial-inactivation capability of BacT/Alert (FA Plus and FN Plus) or Bactec (Plus Aerobic/F and Plus Anaerobic/F) media for 40 antibiotic-bacterium combinations in simulated adult blood cultures. Aside from high recovery rates (93.2% and 88.4%, respectively), we showed that at the lowest but clinically relevant antibiotic concentrations, both BacT/Alert and Bactec media recovered all the organisms tested with drugs except for Escherichia coli, which was tested in the presence of meropenem. Delayed recoveries were mainly associated with vancomycin.

Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number7
DOIs
Publication statusPublished - Jul 2019

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