Efficient microwave combinatorial parallel and nonparallel synthesis of N-alkylated glycine methyl esters as peptide building blocks

Vincenzo Santagada, Francesco Frecentese, Elisa Perissutti, Ferdinando Fiorino, Beatrice Severino, Donatella Cirillo, Sara Terracciano, Giuseppe Caliendo

Research output: Contribution to journalArticlepeer-review

Abstract

An easy and convenient microwave-assisted synthesis of N-alkylated glycine methyl esters is described. Parallel and nonparallel combinatorial methods are described and compared. The described reactions are reductive alkylations of several aldehydes and glycine methyl ester in the presence of NaBH 3CN. Good yields and short reaction times are the main aspects of these procedures.

Original languageEnglish
Pages (from-to)618-621
Number of pages4
JournalJournal of Combinatorial Chemistry
Volume7
Issue number4
DOIs
Publication statusPublished - Jul 2005

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Discrete Mathematics and Combinatorics

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