Efficient microwave combinatorial parallel and nonparallel synthesis of N-alkylated glycine methyl esters as peptide building blocks

Vincenzo Santagada, Francesco Frecentese, Elisa Perissutti, Ferdinando Fiorino, Beatrice Severino, Donatella Cirillo, Sara Terracciano, Giuseppe Caliendo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

An easy and convenient microwave-assisted synthesis of N-alkylated glycine methyl esters is described. Parallel and nonparallel combinatorial methods are described and compared. The described reactions are reductive alkylations of several aldehydes and glycine methyl ester in the presence of NaBH 3CN. Good yields and short reaction times are the main aspects of these procedures.

Original languageEnglish
Pages (from-to)618-621
Number of pages4
JournalJournal of Combinatorial Chemistry
Volume7
Issue number4
DOIs
Publication statusPublished - Jul 2005

Fingerprint

Reaction Time
Microwaves
Peptides
Building Blocks
Microwave
Synthesis
Alkylation
Aldehydes
glycine methyl ester

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Discrete Mathematics and Combinatorics

Cite this

Efficient microwave combinatorial parallel and nonparallel synthesis of N-alkylated glycine methyl esters as peptide building blocks. / Santagada, Vincenzo; Frecentese, Francesco; Perissutti, Elisa; Fiorino, Ferdinando; Severino, Beatrice; Cirillo, Donatella; Terracciano, Sara; Caliendo, Giuseppe.

In: Journal of Combinatorial Chemistry, Vol. 7, No. 4, 07.2005, p. 618-621.

Research output: Contribution to journalArticle

Santagada, V, Frecentese, F, Perissutti, E, Fiorino, F, Severino, B, Cirillo, D, Terracciano, S & Caliendo, G 2005, 'Efficient microwave combinatorial parallel and nonparallel synthesis of N-alkylated glycine methyl esters as peptide building blocks', Journal of Combinatorial Chemistry, vol. 7, no. 4, pp. 618-621. https://doi.org/10.1021/cc050018b
Santagada, Vincenzo ; Frecentese, Francesco ; Perissutti, Elisa ; Fiorino, Ferdinando ; Severino, Beatrice ; Cirillo, Donatella ; Terracciano, Sara ; Caliendo, Giuseppe. / Efficient microwave combinatorial parallel and nonparallel synthesis of N-alkylated glycine methyl esters as peptide building blocks. In: Journal of Combinatorial Chemistry. 2005 ; Vol. 7, No. 4. pp. 618-621.
@article{68d1bbc9ca894f8ea4fd919a502091ba,
title = "Efficient microwave combinatorial parallel and nonparallel synthesis of N-alkylated glycine methyl esters as peptide building blocks",
abstract = "An easy and convenient microwave-assisted synthesis of N-alkylated glycine methyl esters is described. Parallel and nonparallel combinatorial methods are described and compared. The described reactions are reductive alkylations of several aldehydes and glycine methyl ester in the presence of NaBH 3CN. Good yields and short reaction times are the main aspects of these procedures.",
author = "Vincenzo Santagada and Francesco Frecentese and Elisa Perissutti and Ferdinando Fiorino and Beatrice Severino and Donatella Cirillo and Sara Terracciano and Giuseppe Caliendo",
year = "2005",
month = "7",
doi = "10.1021/cc050018b",
language = "English",
volume = "7",
pages = "618--621",
journal = "Journal of Combinatorial Chemistry",
issn = "1520-4766",
publisher = "American Chemical Society",
number = "4",

}

TY - JOUR

T1 - Efficient microwave combinatorial parallel and nonparallel synthesis of N-alkylated glycine methyl esters as peptide building blocks

AU - Santagada, Vincenzo

AU - Frecentese, Francesco

AU - Perissutti, Elisa

AU - Fiorino, Ferdinando

AU - Severino, Beatrice

AU - Cirillo, Donatella

AU - Terracciano, Sara

AU - Caliendo, Giuseppe

PY - 2005/7

Y1 - 2005/7

N2 - An easy and convenient microwave-assisted synthesis of N-alkylated glycine methyl esters is described. Parallel and nonparallel combinatorial methods are described and compared. The described reactions are reductive alkylations of several aldehydes and glycine methyl ester in the presence of NaBH 3CN. Good yields and short reaction times are the main aspects of these procedures.

AB - An easy and convenient microwave-assisted synthesis of N-alkylated glycine methyl esters is described. Parallel and nonparallel combinatorial methods are described and compared. The described reactions are reductive alkylations of several aldehydes and glycine methyl ester in the presence of NaBH 3CN. Good yields and short reaction times are the main aspects of these procedures.

UR - http://www.scopus.com/inward/record.url?scp=22844448796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22844448796&partnerID=8YFLogxK

U2 - 10.1021/cc050018b

DO - 10.1021/cc050018b

M3 - Article

C2 - 16004506

AN - SCOPUS:22844448796

VL - 7

SP - 618

EP - 621

JO - Journal of Combinatorial Chemistry

JF - Journal of Combinatorial Chemistry

SN - 1520-4766

IS - 4

ER -