Efficient transfection of DNA by liposomes formulated with cationic gemini amphiphiles

Cecilia Bombelli, Francesca Faggioli, Paola Luciani, Giovanna Mancini, Maria Grazia Sacco

Research output: Contribution to journalArticle

Abstract

Cationic liposomes formulated with neutral 1,2-dimyristoyl-sn-glycero-3- phosphocholine and cationic gemini surfactants were used for transfecting different cell lines with a reporter gene. The efficiency in the transfection has been correlated to the high extent of DNA condensation observed by circular dichroism, condensation shown to depend heavily on the gemini spacer structure. Transfection efficiency was better than that obtained with a commercial lipofection kit.

Original languageEnglish
Pages (from-to)5378-5382
Number of pages5
JournalJournal of Medicinal Chemistry
Volume48
Issue number16
DOIs
Publication statusPublished - Aug 11 2005

ASJC Scopus subject areas

  • Organic Chemistry

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