EFNS task force: The use of neuroimaging in the diagnosis of dementia

M. Filippi, F. Agosta, F. Barkhof, B. Dubois, N. C. Fox, G. B. Frisoni, C. R. Jack, P. Johannsen, B. L. Miller, P. J. Nestor, P. Scheltens, S. Sorbi, S. Teipel, P. M. Thompson, L. O. Wahlund

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Background and purpose: The European Federation of the Neurological Societies (EFNS) guidelines on the use of neuroimaging in the diagnosis and management of dementia are designed to revise and expand previous EFNS recommendations for the diagnosis and management of patients with Alzheimer's disease (AD) and to provide an overview of the evidence for the use of neuroimaging techniques in non-AD dementias, as well as general recommendations that apply to all types of dementia in clinical practice. Methods: The task force working group reviewed evidence from original research articles, meta-analyses and systematic reviews, published before April 2012. The evidence was classified, and consensus recommendations were given and graded according to the EFNS guidance regulations. Results: Structural imaging, which should be performed at least once in the diagnostic work-up of patients with cognitive impairment, serves to exclude other potentially treatable diseases, to recognize vascular lesions and to identify specific findings to help distinguish different forms of neurodegenerative types of dementia. Although typical cases of dementia may not benefit from routine functional imaging, these tools are recommended in those cases where diagnosis remains in doubt after clinical and structural imaging work-up and in particular clinical settings. Amyloid imaging is likely to find clinical utility in several fields, including the stratification of patients with mild cognitive impairment into those with and without underlying AD and the evaluation of atypical AD presentations. Conclusions: A number of recommendations and good practice points are made to improve the diagnosis of AD and other dementias.

Original languageEnglish
Pages (from-to)1487-1501
Number of pages15
JournalEuropean Journal of Neurology
Volume19
Issue number12
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Advisory Committees
Neuroimaging
Dementia
Alzheimer Disease
Amyloid
Blood Vessels
Meta-Analysis
Consensus
Guidelines
Research

Keywords

  • Alzheimer's disease
  • Amyloid imaging
  • Dementia
  • Diagnosis
  • Guidelines
  • Magnetic resonance imaging
  • Positron emission tomography
  • Single photon emission computed tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

EFNS task force : The use of neuroimaging in the diagnosis of dementia. / Filippi, M.; Agosta, F.; Barkhof, F.; Dubois, B.; Fox, N. C.; Frisoni, G. B.; Jack, C. R.; Johannsen, P.; Miller, B. L.; Nestor, P. J.; Scheltens, P.; Sorbi, S.; Teipel, S.; Thompson, P. M.; Wahlund, L. O.

In: European Journal of Neurology, Vol. 19, No. 12, 12.2012, p. 1487-1501.

Research output: Contribution to journalArticle

Filippi, M, Agosta, F, Barkhof, F, Dubois, B, Fox, NC, Frisoni, GB, Jack, CR, Johannsen, P, Miller, BL, Nestor, PJ, Scheltens, P, Sorbi, S, Teipel, S, Thompson, PM & Wahlund, LO 2012, 'EFNS task force: The use of neuroimaging in the diagnosis of dementia', European Journal of Neurology, vol. 19, no. 12, pp. 1487-1501. https://doi.org/10.1111/j.1468-1331.2012.03859.x
Filippi, M. ; Agosta, F. ; Barkhof, F. ; Dubois, B. ; Fox, N. C. ; Frisoni, G. B. ; Jack, C. R. ; Johannsen, P. ; Miller, B. L. ; Nestor, P. J. ; Scheltens, P. ; Sorbi, S. ; Teipel, S. ; Thompson, P. M. ; Wahlund, L. O. / EFNS task force : The use of neuroimaging in the diagnosis of dementia. In: European Journal of Neurology. 2012 ; Vol. 19, No. 12. pp. 1487-1501.
@article{e529d5f6f12d4698925f175297b86911,
title = "EFNS task force: The use of neuroimaging in the diagnosis of dementia",
abstract = "Background and purpose: The European Federation of the Neurological Societies (EFNS) guidelines on the use of neuroimaging in the diagnosis and management of dementia are designed to revise and expand previous EFNS recommendations for the diagnosis and management of patients with Alzheimer's disease (AD) and to provide an overview of the evidence for the use of neuroimaging techniques in non-AD dementias, as well as general recommendations that apply to all types of dementia in clinical practice. Methods: The task force working group reviewed evidence from original research articles, meta-analyses and systematic reviews, published before April 2012. The evidence was classified, and consensus recommendations were given and graded according to the EFNS guidance regulations. Results: Structural imaging, which should be performed at least once in the diagnostic work-up of patients with cognitive impairment, serves to exclude other potentially treatable diseases, to recognize vascular lesions and to identify specific findings to help distinguish different forms of neurodegenerative types of dementia. Although typical cases of dementia may not benefit from routine functional imaging, these tools are recommended in those cases where diagnosis remains in doubt after clinical and structural imaging work-up and in particular clinical settings. Amyloid imaging is likely to find clinical utility in several fields, including the stratification of patients with mild cognitive impairment into those with and without underlying AD and the evaluation of atypical AD presentations. Conclusions: A number of recommendations and good practice points are made to improve the diagnosis of AD and other dementias.",
keywords = "Alzheimer's disease, Amyloid imaging, Dementia, Diagnosis, Guidelines, Magnetic resonance imaging, Positron emission tomography, Single photon emission computed tomography",
author = "M. Filippi and F. Agosta and F. Barkhof and B. Dubois and Fox, {N. C.} and Frisoni, {G. B.} and Jack, {C. R.} and P. Johannsen and Miller, {B. L.} and Nestor, {P. J.} and P. Scheltens and S. Sorbi and S. Teipel and Thompson, {P. M.} and Wahlund, {L. O.}",
year = "2012",
month = "12",
doi = "10.1111/j.1468-1331.2012.03859.x",
language = "English",
volume = "19",
pages = "1487--1501",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "12",

}

TY - JOUR

T1 - EFNS task force

T2 - The use of neuroimaging in the diagnosis of dementia

AU - Filippi, M.

AU - Agosta, F.

AU - Barkhof, F.

AU - Dubois, B.

AU - Fox, N. C.

AU - Frisoni, G. B.

AU - Jack, C. R.

AU - Johannsen, P.

AU - Miller, B. L.

AU - Nestor, P. J.

AU - Scheltens, P.

AU - Sorbi, S.

AU - Teipel, S.

AU - Thompson, P. M.

AU - Wahlund, L. O.

PY - 2012/12

Y1 - 2012/12

N2 - Background and purpose: The European Federation of the Neurological Societies (EFNS) guidelines on the use of neuroimaging in the diagnosis and management of dementia are designed to revise and expand previous EFNS recommendations for the diagnosis and management of patients with Alzheimer's disease (AD) and to provide an overview of the evidence for the use of neuroimaging techniques in non-AD dementias, as well as general recommendations that apply to all types of dementia in clinical practice. Methods: The task force working group reviewed evidence from original research articles, meta-analyses and systematic reviews, published before April 2012. The evidence was classified, and consensus recommendations were given and graded according to the EFNS guidance regulations. Results: Structural imaging, which should be performed at least once in the diagnostic work-up of patients with cognitive impairment, serves to exclude other potentially treatable diseases, to recognize vascular lesions and to identify specific findings to help distinguish different forms of neurodegenerative types of dementia. Although typical cases of dementia may not benefit from routine functional imaging, these tools are recommended in those cases where diagnosis remains in doubt after clinical and structural imaging work-up and in particular clinical settings. Amyloid imaging is likely to find clinical utility in several fields, including the stratification of patients with mild cognitive impairment into those with and without underlying AD and the evaluation of atypical AD presentations. Conclusions: A number of recommendations and good practice points are made to improve the diagnosis of AD and other dementias.

AB - Background and purpose: The European Federation of the Neurological Societies (EFNS) guidelines on the use of neuroimaging in the diagnosis and management of dementia are designed to revise and expand previous EFNS recommendations for the diagnosis and management of patients with Alzheimer's disease (AD) and to provide an overview of the evidence for the use of neuroimaging techniques in non-AD dementias, as well as general recommendations that apply to all types of dementia in clinical practice. Methods: The task force working group reviewed evidence from original research articles, meta-analyses and systematic reviews, published before April 2012. The evidence was classified, and consensus recommendations were given and graded according to the EFNS guidance regulations. Results: Structural imaging, which should be performed at least once in the diagnostic work-up of patients with cognitive impairment, serves to exclude other potentially treatable diseases, to recognize vascular lesions and to identify specific findings to help distinguish different forms of neurodegenerative types of dementia. Although typical cases of dementia may not benefit from routine functional imaging, these tools are recommended in those cases where diagnosis remains in doubt after clinical and structural imaging work-up and in particular clinical settings. Amyloid imaging is likely to find clinical utility in several fields, including the stratification of patients with mild cognitive impairment into those with and without underlying AD and the evaluation of atypical AD presentations. Conclusions: A number of recommendations and good practice points are made to improve the diagnosis of AD and other dementias.

KW - Alzheimer's disease

KW - Amyloid imaging

KW - Dementia

KW - Diagnosis

KW - Guidelines

KW - Magnetic resonance imaging

KW - Positron emission tomography

KW - Single photon emission computed tomography

UR - http://www.scopus.com/inward/record.url?scp=84869494054&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869494054&partnerID=8YFLogxK

U2 - 10.1111/j.1468-1331.2012.03859.x

DO - 10.1111/j.1468-1331.2012.03859.x

M3 - Article

AN - SCOPUS:84869494054

VL - 19

SP - 1487

EP - 1501

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 12

ER -