Abstract
The over-expression of epidermal growth factor receptor (EGF-R), EGF and transforming growth factor alpha (TGFα) could be a mechanism for colorectal tumor cells to escape normal growth controls. Our aims were: (i) to evaluate EGF, TGFα, and EGF-R concentrations in neoplastic tissue and surrounding mucosa from 40 patients with colorectal adenocarcinoma, and (ii) to assess the expression of these growth factors and their receptor in relation to the tumor site. EGF, TGFα, and EGF-R were detected in either colorectal neoplastic tissue or surrounding mucosa. Significantly increased levels of EGF and EGF-R were present in neoplastic samples compared to surrounding mucosa. Furthermore, a significant increase in TGFα and in EGF levels was observed in the left-sided surrounding mucosa and left-sided neoplastic tissue, respectively. EGF-R stimulation by its ligands may play an important role in colorectal neoplastic tissue. Moreover, the higher content of growth factors in the left-side than the right-side colon suggests different growth properties in the proximal and distal colon.
| Original language | English |
|---|---|
| Pages (from-to) | 285-289 |
| Number of pages | 5 |
| Journal | Acta Oncologica |
| Volume | 37 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1998 |
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ASJC Scopus subject areas
- Oncology
Cite this
EGF, TGF-α, and EGF-R in human colorectal adenocarcinoma. / Messa, Caterina; Russo, Francesco; Caruso, Maria Gabriella; Di Leo, Alfredo.
In: Acta Oncologica, Vol. 37, No. 3, 1998, p. 285-289.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - EGF, TGF-α, and EGF-R in human colorectal adenocarcinoma
AU - Messa, Caterina
AU - Russo, Francesco
AU - Caruso, Maria Gabriella
AU - Di Leo, Alfredo
PY - 1998
Y1 - 1998
N2 - The over-expression of epidermal growth factor receptor (EGF-R), EGF and transforming growth factor alpha (TGFα) could be a mechanism for colorectal tumor cells to escape normal growth controls. Our aims were: (i) to evaluate EGF, TGFα, and EGF-R concentrations in neoplastic tissue and surrounding mucosa from 40 patients with colorectal adenocarcinoma, and (ii) to assess the expression of these growth factors and their receptor in relation to the tumor site. EGF, TGFα, and EGF-R were detected in either colorectal neoplastic tissue or surrounding mucosa. Significantly increased levels of EGF and EGF-R were present in neoplastic samples compared to surrounding mucosa. Furthermore, a significant increase in TGFα and in EGF levels was observed in the left-sided surrounding mucosa and left-sided neoplastic tissue, respectively. EGF-R stimulation by its ligands may play an important role in colorectal neoplastic tissue. Moreover, the higher content of growth factors in the left-side than the right-side colon suggests different growth properties in the proximal and distal colon.
AB - The over-expression of epidermal growth factor receptor (EGF-R), EGF and transforming growth factor alpha (TGFα) could be a mechanism for colorectal tumor cells to escape normal growth controls. Our aims were: (i) to evaluate EGF, TGFα, and EGF-R concentrations in neoplastic tissue and surrounding mucosa from 40 patients with colorectal adenocarcinoma, and (ii) to assess the expression of these growth factors and their receptor in relation to the tumor site. EGF, TGFα, and EGF-R were detected in either colorectal neoplastic tissue or surrounding mucosa. Significantly increased levels of EGF and EGF-R were present in neoplastic samples compared to surrounding mucosa. Furthermore, a significant increase in TGFα and in EGF levels was observed in the left-sided surrounding mucosa and left-sided neoplastic tissue, respectively. EGF-R stimulation by its ligands may play an important role in colorectal neoplastic tissue. Moreover, the higher content of growth factors in the left-side than the right-side colon suggests different growth properties in the proximal and distal colon.
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U2 - 10.1080/028418698429595
DO - 10.1080/028418698429595
M3 - Article
C2 - 9677101
AN - SCOPUS:0031800885
VL - 37
SP - 285
EP - 289
JO - Acta Oncologica
JF - Acta Oncologica
SN - 0284-186X
IS - 3
ER -