EGFR tyrosine kinase inhibitors beyond focal progression obtain a prolonged disease control in patients with advanced adenocarcinoma of the lung

Fabio Conforti, Chiara Catania, Francesca Toffalorio, Matteo Duca, Gianluca Spitaleri, Massimo Barberis, Cristina Noberasco, Angelo Delmonte, Mariacarmela Santarpia, Chiara Lazzari, Tommaso Martino De Pas

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Recent data show that EGFR pathway and its inhibition maintain their role after progression of disease during EGFR TKI therapy in NSCLCs. We conducted a retrospective study with the aim of evaluating efficacy and feasibility of prosecution of EGFR TKI therapy beyond focal progression associated to locoregional radiotherapy. Methods: We retrospectively analyzed the data of all NSCLC patients treated with EGFR TKIs in our institution from 2004 to 2012. We included in the analysis patients that after a focal disease progression, meant as a single lesion RECIST progression, have been treated with definitive locoregional radiotherapy, associated to continuation of EGFR TKI therapy until further progression. Results: 15 out of 147 patients (10%) satisfied inclusion criteria. The median progression free survival, measured from the date of focal progression until further progression of disease or death by any cause, was 10,9 months (range 3-32 months). The corresponding 6 and 12 months PFS rates were 73% and 33%, respectively. Conclusion: The longer disease control observed in our patients suggests that continuation of EGFR TKI beyond focal progression associated to a locoregional treatment is an efficacious therapeutic strategy.

Original languageEnglish
Pages (from-to)440-444
Number of pages5
JournalLung Cancer
Volume81
Issue number3
DOIs
Publication statusPublished - Sep 2013

Keywords

  • Advanced lung adenocarcinoma
  • Beyond progression
  • Erlotinib
  • Gefitinib
  • Lung adenocarcinoma
  • Radiotherapy
  • TKI therapy

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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