EGFR/ERBB receptors differentially modulate sebaceous lipogenesis

Maik Dahlhoff, Emanuela Camera, Matteo Ludovici, Mauro Picardo, Udo Müller, Heinrich Leonhardt, Christos C. Zouboulis, Marlon R. Schneider

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile red staining showed that siRNA-mediated downregulation of EGFR or ERBB3 increases lipid accumulation, whereas ERBB2 downregulation has no effect. Spectrometry confirmed induction of triglycerides after EGFR or ERBB3 downregulation and revealed induction of cholesteryl esters after downregulation of EGFR, ERBB2 or ERBB3. Thus, EGFR/ERBB receptors differentially modulate sebaceous lipogenesis, a key feature of sebaceous gland physiology and of several skin diseases.

Original languageEnglish
Article number37097
Pages (from-to)1376-1382
Number of pages7
JournalFEBS Letters
Volume589
Issue number12
DOIs
Publication statusPublished - May 22 2015

Keywords

  • Epidermal growth factor receptor
  • ERBB
  • Sebaceous gland
  • Sebaceous lipogenesis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology
  • Medicine(all)

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