EGFR/ERBB receptors differentially modulate sebaceous lipogenesis

Maik Dahlhoff, Emanuela Camera, Matteo Ludovici, Mauro Picardo, Udo Müller, Heinrich Leonhardt, Christos C. Zouboulis, Marlon R. Schneider

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Abstract The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile red staining showed that siRNA-mediated downregulation of EGFR or ERBB3 increases lipid accumulation, whereas ERBB2 downregulation has no effect. Spectrometry confirmed induction of triglycerides after EGFR or ERBB3 downregulation and revealed induction of cholesteryl esters after downregulation of EGFR, ERBB2 or ERBB3. Thus, EGFR/ERBB receptors differentially modulate sebaceous lipogenesis, a key feature of sebaceous gland physiology and of several skin diseases.

Original languageEnglish
Article number37097
Pages (from-to)1376-1382
Number of pages7
JournalFEBS Letters
Volume589
Issue number12
DOIs
Publication statusPublished - May 22 2015

Fingerprint

Lipogenesis
Epidermal Growth Factor Receptor
Down-Regulation
Sebaceous Glands
Lipids
Cholesterol Esters
Physiology
Skin Diseases
Spectrometry
Small Interfering RNA
Spectrum Analysis
Skin
Triglycerides
Staining and Labeling

Keywords

  • Epidermal growth factor receptor
  • ERBB
  • Sebaceous gland
  • Sebaceous lipogenesis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology
  • Medicine(all)

Cite this

Dahlhoff, M., Camera, E., Ludovici, M., Picardo, M., Müller, U., Leonhardt, H., ... Schneider, M. R. (2015). EGFR/ERBB receptors differentially modulate sebaceous lipogenesis. FEBS Letters, 589(12), 1376-1382. [37097]. https://doi.org/10.1016/j.febslet.2015.04.003

EGFR/ERBB receptors differentially modulate sebaceous lipogenesis. / Dahlhoff, Maik; Camera, Emanuela; Ludovici, Matteo; Picardo, Mauro; Müller, Udo; Leonhardt, Heinrich; Zouboulis, Christos C.; Schneider, Marlon R.

In: FEBS Letters, Vol. 589, No. 12, 37097, 22.05.2015, p. 1376-1382.

Research output: Contribution to journalArticle

Dahlhoff, M, Camera, E, Ludovici, M, Picardo, M, Müller, U, Leonhardt, H, Zouboulis, CC & Schneider, MR 2015, 'EGFR/ERBB receptors differentially modulate sebaceous lipogenesis', FEBS Letters, vol. 589, no. 12, 37097, pp. 1376-1382. https://doi.org/10.1016/j.febslet.2015.04.003
Dahlhoff M, Camera E, Ludovici M, Picardo M, Müller U, Leonhardt H et al. EGFR/ERBB receptors differentially modulate sebaceous lipogenesis. FEBS Letters. 2015 May 22;589(12):1376-1382. 37097. https://doi.org/10.1016/j.febslet.2015.04.003
Dahlhoff, Maik ; Camera, Emanuela ; Ludovici, Matteo ; Picardo, Mauro ; Müller, Udo ; Leonhardt, Heinrich ; Zouboulis, Christos C. ; Schneider, Marlon R. / EGFR/ERBB receptors differentially modulate sebaceous lipogenesis. In: FEBS Letters. 2015 ; Vol. 589, No. 12. pp. 1376-1382.
@article{0eb730f30ad74eea99e99e2a1d60f530,
title = "EGFR/ERBB receptors differentially modulate sebaceous lipogenesis",
abstract = "Abstract The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile red staining showed that siRNA-mediated downregulation of EGFR or ERBB3 increases lipid accumulation, whereas ERBB2 downregulation has no effect. Spectrometry confirmed induction of triglycerides after EGFR or ERBB3 downregulation and revealed induction of cholesteryl esters after downregulation of EGFR, ERBB2 or ERBB3. Thus, EGFR/ERBB receptors differentially modulate sebaceous lipogenesis, a key feature of sebaceous gland physiology and of several skin diseases.",
keywords = "Epidermal growth factor receptor, ERBB, Sebaceous gland, Sebaceous lipogenesis",
author = "Maik Dahlhoff and Emanuela Camera and Matteo Ludovici and Mauro Picardo and Udo M{\"u}ller and Heinrich Leonhardt and Zouboulis, {Christos C.} and Schneider, {Marlon R.}",
year = "2015",
month = "5",
day = "22",
doi = "10.1016/j.febslet.2015.04.003",
language = "English",
volume = "589",
pages = "1376--1382",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "12",

}

TY - JOUR

T1 - EGFR/ERBB receptors differentially modulate sebaceous lipogenesis

AU - Dahlhoff, Maik

AU - Camera, Emanuela

AU - Ludovici, Matteo

AU - Picardo, Mauro

AU - Müller, Udo

AU - Leonhardt, Heinrich

AU - Zouboulis, Christos C.

AU - Schneider, Marlon R.

PY - 2015/5/22

Y1 - 2015/5/22

N2 - Abstract The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile red staining showed that siRNA-mediated downregulation of EGFR or ERBB3 increases lipid accumulation, whereas ERBB2 downregulation has no effect. Spectrometry confirmed induction of triglycerides after EGFR or ERBB3 downregulation and revealed induction of cholesteryl esters after downregulation of EGFR, ERBB2 or ERBB3. Thus, EGFR/ERBB receptors differentially modulate sebaceous lipogenesis, a key feature of sebaceous gland physiology and of several skin diseases.

AB - Abstract The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile red staining showed that siRNA-mediated downregulation of EGFR or ERBB3 increases lipid accumulation, whereas ERBB2 downregulation has no effect. Spectrometry confirmed induction of triglycerides after EGFR or ERBB3 downregulation and revealed induction of cholesteryl esters after downregulation of EGFR, ERBB2 or ERBB3. Thus, EGFR/ERBB receptors differentially modulate sebaceous lipogenesis, a key feature of sebaceous gland physiology and of several skin diseases.

KW - Epidermal growth factor receptor

KW - ERBB

KW - Sebaceous gland

KW - Sebaceous lipogenesis

UR - http://www.scopus.com/inward/record.url?scp=84937762868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937762868&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2015.04.003

DO - 10.1016/j.febslet.2015.04.003

M3 - Article

VL - 589

SP - 1376

EP - 1382

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 12

M1 - 37097

ER -