EGFR/ERBB receptors differentially modulate sebaceous lipogenesis

Maik Dahlhoff; Emanuela Camera; Matteo Ludovici; Mauro Picardo; Udo Müller; Heinrich Leonhardt; Christos C. Zouboulis; Marlon R. Schneider

doi:10.1016/j.febslet.2015.04.003

EGFR/ERBB receptors differentially modulate sebaceous lipogenesis

Maik Dahlhoff, Emanuela Camera, Matteo Ludovici, Mauro Picardo, Udo Müller, Heinrich Leonhardt, Christos C. Zouboulis, Marlon R. Schneider

Istituto S. Maria e S. Gallicano

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile red staining showed that siRNA-mediated downregulation of EGFR or ERBB3 increases lipid accumulation, whereas ERBB2 downregulation has no effect. Spectrometry confirmed induction of triglycerides after EGFR or ERBB3 downregulation and revealed induction of cholesteryl esters after downregulation of EGFR, ERBB2 or ERBB3. Thus, EGFR/ERBB receptors differentially modulate sebaceous lipogenesis, a key feature of sebaceous gland physiology and of several skin diseases.

Original language	English
Article number	37097
Pages (from-to)	1376-1382
Number of pages	7
Journal	FEBS Letters
Volume	589
Issue number	12
DOIs	https://doi.org/10.1016/j.febslet.2015.04.003
Publication status	Published - May 22 2015

Keywords

Epidermal growth factor receptor
ERBB
Sebaceous gland
Sebaceous lipogenesis

ASJC Scopus subject areas

Biochemistry
Biophysics
Cell Biology
Genetics
Molecular Biology
Structural Biology
Medicine(all)

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10.1016/j.febslet.2015.04.003

Cite this

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title = "EGFR/ERBB receptors differentially modulate sebaceous lipogenesis",

abstract = "Abstract The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile red staining showed that siRNA-mediated downregulation of EGFR or ERBB3 increases lipid accumulation, whereas ERBB2 downregulation has no effect. Spectrometry confirmed induction of triglycerides after EGFR or ERBB3 downregulation and revealed induction of cholesteryl esters after downregulation of EGFR, ERBB2 or ERBB3. Thus, EGFR/ERBB receptors differentially modulate sebaceous lipogenesis, a key feature of sebaceous gland physiology and of several skin diseases.",

keywords = "Epidermal growth factor receptor, ERBB, Sebaceous gland, Sebaceous lipogenesis",

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T1 - EGFR/ERBB receptors differentially modulate sebaceous lipogenesis

AU - Dahlhoff, Maik

AU - Camera, Emanuela

AU - Ludovici, Matteo

AU - Picardo, Mauro

AU - Müller, Udo

AU - Leonhardt, Heinrich

AU - Zouboulis, Christos C.

AU - Schneider, Marlon R.

PY - 2015/5/22

Y1 - 2015/5/22

N2 - Abstract The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile red staining showed that siRNA-mediated downregulation of EGFR or ERBB3 increases lipid accumulation, whereas ERBB2 downregulation has no effect. Spectrometry confirmed induction of triglycerides after EGFR or ERBB3 downregulation and revealed induction of cholesteryl esters after downregulation of EGFR, ERBB2 or ERBB3. Thus, EGFR/ERBB receptors differentially modulate sebaceous lipogenesis, a key feature of sebaceous gland physiology and of several skin diseases.

AB - Abstract The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile red staining showed that siRNA-mediated downregulation of EGFR or ERBB3 increases lipid accumulation, whereas ERBB2 downregulation has no effect. Spectrometry confirmed induction of triglycerides after EGFR or ERBB3 downregulation and revealed induction of cholesteryl esters after downregulation of EGFR, ERBB2 or ERBB3. Thus, EGFR/ERBB receptors differentially modulate sebaceous lipogenesis, a key feature of sebaceous gland physiology and of several skin diseases.

KW - Epidermal growth factor receptor

KW - ERBB

KW - Sebaceous gland

KW - Sebaceous lipogenesis

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EGFR/ERBB receptors differentially modulate sebaceous lipogenesis

Abstract

Keywords

ASJC Scopus subject areas

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