Eight-hours adaptive deep brain stimulation in patients with Parkinson disease

Mattia Arlotti, Sara Marceglia, Guglielmo Foffani, Jens Volkmann, Andres M. Lozano, Elena Moro, Filippo Cogiamanian, Marco Prenassi, Tommaso Bocci, Francesca Cortese, Paolo Rampini, Sergio Barbieri, Alberto Priori

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Abstract

Objectives To assess the feasibility and clinical efficacy of local field potentials (LFPs)-based adaptive deep brain stimulation (aDBS) in patients with advanced Parkinson disease (PD) during daily activities in an open-label, nonblinded study. Methods We monitored neurophysiologic and clinical fluctuations during 2 perioperative experimental sessions lasting for up to 8 hours. On the first day, the patient took his/her daily medication, while on the second, he/she additionally underwent subthalamic nucleus aDBS driven by LFPs beta band power. Results The beta band power correlated in both experimental sessions with the patient's clinical state (Pearson correlation coefficient r = 0.506, p < 0.001, and r = 0.477, p < 0.001). aDBS after LFP changes was effective (30% improvement without medication [3-way analysis of variance, interaction day × medication p = 0.036; 30.5 ± 3.4 vs 22.2 ± 3.3, p = 0.003]), safe, and well tolerated in patients performing regular daily activities and taking additional dopaminergic medication. aDBS was able to decrease DBS amplitude during motor "on" states compared to "off" states (paired t test p = 0.046), and this automatic adjustment of STN-DBS prevented dyskinesias. Conclusions The main findings of our study are that aDBS is technically feasible in everyday life and provides a safe, well-Tolerated, and effective treatment method for the management of clinical fluctuations. Classification of evidence This study provides Class IV evidence that for patients with advanced PD, aDBS is safe, well tolerated, and effective in controlling PD motor symptoms.

Original languageEnglish
Pages (from-to)e971-e976
JournalNeurology
Volume90
Issue number11
DOIs
Publication statusPublished - Mar 13 2018

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Deep Brain Stimulation
Parkinson Disease
Subthalamic Nucleus
Dyskinesias
Analysis of Variance

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Arlotti, M., Marceglia, S., Foffani, G., Volkmann, J., Lozano, A. M., Moro, E., ... Priori, A. (2018). Eight-hours adaptive deep brain stimulation in patients with Parkinson disease. Neurology, 90(11), e971-e976. https://doi.org/10.1212/WNL.0000000000005121

Eight-hours adaptive deep brain stimulation in patients with Parkinson disease. / Arlotti, Mattia; Marceglia, Sara; Foffani, Guglielmo; Volkmann, Jens; Lozano, Andres M.; Moro, Elena; Cogiamanian, Filippo; Prenassi, Marco; Bocci, Tommaso; Cortese, Francesca; Rampini, Paolo; Barbieri, Sergio; Priori, Alberto.

In: Neurology, Vol. 90, No. 11, 13.03.2018, p. e971-e976.

Research output: Contribution to journalArticle

Arlotti, M, Marceglia, S, Foffani, G, Volkmann, J, Lozano, AM, Moro, E, Cogiamanian, F, Prenassi, M, Bocci, T, Cortese, F, Rampini, P, Barbieri, S & Priori, A 2018, 'Eight-hours adaptive deep brain stimulation in patients with Parkinson disease', Neurology, vol. 90, no. 11, pp. e971-e976. https://doi.org/10.1212/WNL.0000000000005121
Arlotti M, Marceglia S, Foffani G, Volkmann J, Lozano AM, Moro E et al. Eight-hours adaptive deep brain stimulation in patients with Parkinson disease. Neurology. 2018 Mar 13;90(11):e971-e976. https://doi.org/10.1212/WNL.0000000000005121
Arlotti, Mattia ; Marceglia, Sara ; Foffani, Guglielmo ; Volkmann, Jens ; Lozano, Andres M. ; Moro, Elena ; Cogiamanian, Filippo ; Prenassi, Marco ; Bocci, Tommaso ; Cortese, Francesca ; Rampini, Paolo ; Barbieri, Sergio ; Priori, Alberto. / Eight-hours adaptive deep brain stimulation in patients with Parkinson disease. In: Neurology. 2018 ; Vol. 90, No. 11. pp. e971-e976.
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