Eight-years failure of subthalamic stimulation rescued by globus pallidus implant

Brigida Minafra, Alfonso Fasano, Nicolò Gabriele Pozzi, Roberta Zangaglia, Domenico Servello, Claudio Pacchetti

Research output: Contribution to journalArticlepeer-review


Background Deep brain stimulation is the surgical procedure of choice in patients with Parkinson's disease. The subthalamic nucleus and the globus pallidus interna are the two most common targets used to treat Parkinson's disease. Methods We describe three patients with previous effective subthalamic deep brain stimulation in whom globus pallidus interna deep brain stimulation was performed as "rescue" surgery, 8 years after the original operation. Results Two years after globus pallidus surgery the reduction of dystonia and dyskinesias led to an improvement of motor symptoms. In two patients, painful dystonias disappeared and motor fluctuations markedly improved. One patient achieved an improvement in freezing. Conclusion After 24 months of follow up, our observations suggest that globus pallidus deep brain stimulation, can improve motor fluctuations, dyskinesia and axial symptoms.

Original languageEnglish
Pages (from-to)179-181
Number of pages3
JournalBrain Stimulation
Issue number2
Publication statusPublished - 2014


  • Deep brain stimulation
  • Globus pallidus interna
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Biophysics
  • Medicine(all)


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