This study deals with the relationship between elastase levels and catabolism of GPlb during the storage period in three types of platelet concentrates. Leucocyte contamination has been found to be associated with the release of a quantity of elastase, that is already detectable at day +1 of storage. Such an enzyme is able to promote hypercatabolism of GPlb and glycocalicin (i.e., the proteolytic split product of GPlb).
|Translated title of the contribution||Elastase and catabolic changes of GPIb in platelet concentrates for blood transfusion|
|Number of pages||4|
|Journal||Trasfusione del Sangue|
|Publication status||Published - 1999|
ASJC Scopus subject areas
- Immunology and Allergy