Elderly patients with acute coronary syndromes admitted to Italian intensive cardiac care units: A Blitz-3 registry sub-analysis

Gianni Casella, Giampaolo Scorcu, Matteo Cassin, Francesco Chiarella, Alessandra Chinaglia, Maria R. Conte, Giuseppe Fradella, Donata Lucci, Aldo P. Maggioni, Luigi O. Visconti

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Guideline-recommended therapies for acute coronary syndromes (ACS) derive from randomized trials in which elderly patients are underrepresented. Although numbers of this population are increasing, they are largely undertreated in the real world. OBJECTIVE: The study evaluates the impact of older age on care for patients with ACS admitted to the Italian Intensive Cardiac Care Units (ICCUs) network. METHODS: We analyzed data from the BLITZ-3 Registry in order to assess in-hospital care among unselected elderly patients (≥75 years). RESULTS: From 7-20 April 2008, 6986 consecutive patients with acute cardiac conditions were admitted to ICCUs and prospectively enrolled; 3636 (52%) had ACS and 38% of them were elderly. Elderly patients had a higher risk profile, their median length of stay in ICCU was longer [4 days, interquartile range (IQR): 3-6 vs. 3 days, IQR: 2-5; P <0.0001] and guideline-recommended care was applied less often. At multivariable analysis, elderly patients were less likely to receive reperfusion [odds ratio (OR) = 0.53, 95% confidence interval (CI) = 0.42-0.67] for ST-elevation, or early coronary angiography (OR = 0.45, 95% CI = 0.37-0.56) for non-ST elevation ACS. Besides, unadjusted in-ICCU total mortality was higher for elderly patients with ST-elevation (11.8% elderly vs. 1.8% younger patients; P <0.0001) or non-ST-elevation (3.9% elderly vs. 0.6% younger patients; P <0.0001) ACS. CONCLUSION: In a nationwide survey, age impacts on care. The elderly with ACS have a higher risk profile but receive less guideline-recommended care than younger patients. Thus, further improvements in care of this population should be pursued.

Original languageEnglish
JournalJournal of Cardiovascular Medicine
DOIs
Publication statusAccepted/In press - Feb 2 2012

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Acute Coronary Syndrome
Intensive Care Units
Registries
Guidelines
Patient Care
Odds Ratio
Confidence Intervals
Coronary Angiography
Population
Reperfusion
Length of Stay
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Elderly patients with acute coronary syndromes admitted to Italian intensive cardiac care units : A Blitz-3 registry sub-analysis. / Casella, Gianni; Scorcu, Giampaolo; Cassin, Matteo; Chiarella, Francesco; Chinaglia, Alessandra; Conte, Maria R.; Fradella, Giuseppe; Lucci, Donata; Maggioni, Aldo P.; Visconti, Luigi O.

In: Journal of Cardiovascular Medicine, 02.02.2012.

Research output: Contribution to journalArticle

Casella, Gianni ; Scorcu, Giampaolo ; Cassin, Matteo ; Chiarella, Francesco ; Chinaglia, Alessandra ; Conte, Maria R. ; Fradella, Giuseppe ; Lucci, Donata ; Maggioni, Aldo P. ; Visconti, Luigi O. / Elderly patients with acute coronary syndromes admitted to Italian intensive cardiac care units : A Blitz-3 registry sub-analysis. In: Journal of Cardiovascular Medicine. 2012.
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abstract = "BACKGROUND: Guideline-recommended therapies for acute coronary syndromes (ACS) derive from randomized trials in which elderly patients are underrepresented. Although numbers of this population are increasing, they are largely undertreated in the real world. OBJECTIVE: The study evaluates the impact of older age on care for patients with ACS admitted to the Italian Intensive Cardiac Care Units (ICCUs) network. METHODS: We analyzed data from the BLITZ-3 Registry in order to assess in-hospital care among unselected elderly patients (≥75 years). RESULTS: From 7-20 April 2008, 6986 consecutive patients with acute cardiac conditions were admitted to ICCUs and prospectively enrolled; 3636 (52{\%}) had ACS and 38{\%} of them were elderly. Elderly patients had a higher risk profile, their median length of stay in ICCU was longer [4 days, interquartile range (IQR): 3-6 vs. 3 days, IQR: 2-5; P <0.0001] and guideline-recommended care was applied less often. At multivariable analysis, elderly patients were less likely to receive reperfusion [odds ratio (OR) = 0.53, 95{\%} confidence interval (CI) = 0.42-0.67] for ST-elevation, or early coronary angiography (OR = 0.45, 95{\%} CI = 0.37-0.56) for non-ST elevation ACS. Besides, unadjusted in-ICCU total mortality was higher for elderly patients with ST-elevation (11.8{\%} elderly vs. 1.8{\%} younger patients; P <0.0001) or non-ST-elevation (3.9{\%} elderly vs. 0.6{\%} younger patients; P <0.0001) ACS. CONCLUSION: In a nationwide survey, age impacts on care. The elderly with ACS have a higher risk profile but receive less guideline-recommended care than younger patients. Thus, further improvements in care of this population should be pursued.",
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T1 - Elderly patients with acute coronary syndromes admitted to Italian intensive cardiac care units

T2 - A Blitz-3 registry sub-analysis

AU - Casella, Gianni

AU - Scorcu, Giampaolo

AU - Cassin, Matteo

AU - Chiarella, Francesco

AU - Chinaglia, Alessandra

AU - Conte, Maria R.

AU - Fradella, Giuseppe

AU - Lucci, Donata

AU - Maggioni, Aldo P.

AU - Visconti, Luigi O.

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N2 - BACKGROUND: Guideline-recommended therapies for acute coronary syndromes (ACS) derive from randomized trials in which elderly patients are underrepresented. Although numbers of this population are increasing, they are largely undertreated in the real world. OBJECTIVE: The study evaluates the impact of older age on care for patients with ACS admitted to the Italian Intensive Cardiac Care Units (ICCUs) network. METHODS: We analyzed data from the BLITZ-3 Registry in order to assess in-hospital care among unselected elderly patients (≥75 years). RESULTS: From 7-20 April 2008, 6986 consecutive patients with acute cardiac conditions were admitted to ICCUs and prospectively enrolled; 3636 (52%) had ACS and 38% of them were elderly. Elderly patients had a higher risk profile, their median length of stay in ICCU was longer [4 days, interquartile range (IQR): 3-6 vs. 3 days, IQR: 2-5; P <0.0001] and guideline-recommended care was applied less often. At multivariable analysis, elderly patients were less likely to receive reperfusion [odds ratio (OR) = 0.53, 95% confidence interval (CI) = 0.42-0.67] for ST-elevation, or early coronary angiography (OR = 0.45, 95% CI = 0.37-0.56) for non-ST elevation ACS. Besides, unadjusted in-ICCU total mortality was higher for elderly patients with ST-elevation (11.8% elderly vs. 1.8% younger patients; P <0.0001) or non-ST-elevation (3.9% elderly vs. 0.6% younger patients; P <0.0001) ACS. CONCLUSION: In a nationwide survey, age impacts on care. The elderly with ACS have a higher risk profile but receive less guideline-recommended care than younger patients. Thus, further improvements in care of this population should be pursued.

AB - BACKGROUND: Guideline-recommended therapies for acute coronary syndromes (ACS) derive from randomized trials in which elderly patients are underrepresented. Although numbers of this population are increasing, they are largely undertreated in the real world. OBJECTIVE: The study evaluates the impact of older age on care for patients with ACS admitted to the Italian Intensive Cardiac Care Units (ICCUs) network. METHODS: We analyzed data from the BLITZ-3 Registry in order to assess in-hospital care among unselected elderly patients (≥75 years). RESULTS: From 7-20 April 2008, 6986 consecutive patients with acute cardiac conditions were admitted to ICCUs and prospectively enrolled; 3636 (52%) had ACS and 38% of them were elderly. Elderly patients had a higher risk profile, their median length of stay in ICCU was longer [4 days, interquartile range (IQR): 3-6 vs. 3 days, IQR: 2-5; P <0.0001] and guideline-recommended care was applied less often. At multivariable analysis, elderly patients were less likely to receive reperfusion [odds ratio (OR) = 0.53, 95% confidence interval (CI) = 0.42-0.67] for ST-elevation, or early coronary angiography (OR = 0.45, 95% CI = 0.37-0.56) for non-ST elevation ACS. Besides, unadjusted in-ICCU total mortality was higher for elderly patients with ST-elevation (11.8% elderly vs. 1.8% younger patients; P <0.0001) or non-ST-elevation (3.9% elderly vs. 0.6% younger patients; P <0.0001) ACS. CONCLUSION: In a nationwide survey, age impacts on care. The elderly with ACS have a higher risk profile but receive less guideline-recommended care than younger patients. Thus, further improvements in care of this population should be pursued.

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