Elective partial nephrectomy is equivalent to radical nephrectomy in patients with clinical T1 renal cell carcinoma: Results of a retrospective, comparative, multi-institutional study

Alessandro Antonelli, Vincenzo Ficarra, Roberto Bertini, Marco Carini, Giorgio Carmignani, Serena Corti, Nicola Longo, Giuseppe Martorana, Andrea Minervini, Vincenzo Mirone, Giacomo Novara, Sergio Serni, Claudio Simeone, Alchiede Simonato, Salvatore Siracusano, Alessandro Volpe, Filiberto Zattoni, Sergio Cosciani Cunico

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Abstract

Objective To compare the oncological outcomes of patients who underwent elective partial nephrectomy (PN) or radical nephrectomy (RN) for clinically organ-confined renal masses ≥7 cm in size (cT1). Patients and Methods The records of 3480 patients with cT1N0M0 disease were extracted from a multi-institutional database and analyzed retrospectively. Results In patients who underwent PN, the risk of clinical understaging was 3.2% in cT1a cases and 10.6% in cT1b cases. With regard to the cT1a patients, the 5- and 10-year cancer-specific survival (CSS) estimates were 94.7% and 90.4%, respectively, after RN and 96.1% and 94.9%, respectively, after PN (log-rank test: P = 0.01). With regard to cT1b patients, the 5-year CSS probabilities were 92.6% after RN and 90% after PN, respectively (log-rank test: P = 0.89). Surgical treatment failed to be an independent predictor of CSS on multivariable analysis, both for cT1a and cT1b patients. Interestingly, PN was oncologically equivalent to RN also in patients with pT3a tumours (log-rank test: P = 0.91). Conclusions Elective PN is not associated with an increased risk of recurrence and cancer-specific mortality in both cT1a and cT1b tumours. Data from the present study strongly support the use of partial nephrectomy in patients with clinically T1 tumours, according to the current recommendations of the international guidelines.

Original languageEnglish
Pages (from-to)1013-1018
Number of pages6
JournalBJU International
Volume109
Issue number7
DOIs
Publication statusPublished - Apr 2012

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Keywords

  • clinical staging
  • nephron-sparing surgery
  • partial nephrectomy
  • radical nephrectomy
  • renal cancer

ASJC Scopus subject areas

  • Urology

Cite this

Antonelli, A., Ficarra, V., Bertini, R., Carini, M., Carmignani, G., Corti, S., Longo, N., Martorana, G., Minervini, A., Mirone, V., Novara, G., Serni, S., Simeone, C., Simonato, A., Siracusano, S., Volpe, A., Zattoni, F., & Cunico, S. C. (2012). Elective partial nephrectomy is equivalent to radical nephrectomy in patients with clinical T1 renal cell carcinoma: Results of a retrospective, comparative, multi-institutional study. BJU International, 109(7), 1013-1018. https://doi.org/10.1111/j.1464-410X.2011.10431.x