Electrical characterization of DNA-functionalized solid state nanopores for bio-sensing

V. Mussi, P. Fanzio, L. Repetto, G. Firpo, P. Scaruffi, S. Stigliani, M. Menotta, M. Magnani, G. P. Tonini, U. Valbusa

Research output: Contribution to journalArticlepeer-review

Abstract

We present data concerning the electrical properties of a class of biosensor devices based on bio-functionalized solid state nanopores able to detect different kinds of interactions between probe molecules, chemically attached to the pore surface, and target molecules present in solution and electrophoretically drawn through the nanometric channel. The great potentiality of this approach resides in the fact that the functionalization of a quite large pore (up to 50-60 nm) allows a sufficient diameter reduction for the attainment of a single molecule sensing dimension and selective activation, without the need for further material deposition, such as metal or oxides, or localized surface modification. The results indicate that it will be possible, in the near future, to conceive and design devices for parallel analysis of biological samples made of arrays of nanopores differently functionalized, fabricated by standard lithographic techniques, with important applications in the field of molecular diagnosis.

Original languageEnglish
Article number454104
JournalJournal of Physics Condensed Matter
Volume22
Issue number45
DOIs
Publication statusPublished - Nov 17 2010

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Materials Science(all)
  • Medicine(all)

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