Electrical stimulation of midbrain raphe

Biochemical, behavioral and bioelectrical effects

W. Kostowski, E. Giacalone, S. Garattini, L. Valzelli

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Electrical stimulation of MR in rats induces a marked increase of 5HIAA and a decrease of 5HT in the forebrain. At the same time the onset of electroencephalographic pattern of sleep and behavioral signs of calmness were observed. The most intense biochemical effects were obtained with 10 c/sec stimulation whereas 2 c/sec stimulation produced the clearest behavioral depression.{A table is presented}.

Original languageEnglish
Pages (from-to)170-175
Number of pages6
JournalEuropean Journal of Pharmacology
Volume7
Issue number2
Publication statusPublished - Aug 1969

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Prosencephalon
Electric Stimulation
Sleep
Depression
Midbrain Raphe Nuclei

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Electrical stimulation of midbrain raphe : Biochemical, behavioral and bioelectrical effects. / Kostowski, W.; Giacalone, E.; Garattini, S.; Valzelli, L.

In: European Journal of Pharmacology, Vol. 7, No. 2, 08.1969, p. 170-175.

Research output: Contribution to journalArticle

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