Electrical stimulation of midbrain raphe: Biochemical, behavioral and bioelectrical effects

W. Kostowski, E. Giacalone, S. Garattini, L. Valzelli

Research output: Contribution to journalArticlepeer-review

Abstract

Electrical stimulation of MR in rats induces a marked increase of 5HIAA and a decrease of 5HT in the forebrain. At the same time the onset of electroencephalographic pattern of sleep and behavioral signs of calmness were observed. The most intense biochemical effects were obtained with 10 c/sec stimulation whereas 2 c/sec stimulation produced the clearest behavioral depression.{A table is presented}.

Original languageEnglish
Pages (from-to)170-175
Number of pages6
JournalEuropean Journal of Pharmacology
Volume7
Issue number2
Publication statusPublished - Aug 1969

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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