Electrical stimulation over muscle tendons in humans. Evidence favouring presynaptic inhibition of Ia fibres due to the activation of group III tendon afferents

Alberto Priori, Alfredo Berardelli, Maurizio Inghilleri, Francesca Pedace, Morena Giovannelli, Mario Manfredi

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Electrical stimulation over muscle tendons produces a transient suppression of voluntary EMG activity; its onset latency is ~55 ms in the forearm extensor muscles. This phenomenon has been attributed to the activation of a polysynaptic inhibitory pathway originating from Ib afferent fibres. To clarify its origin we conducted several experiments in 10 normal healthy subjects. The EMG silence after tendon stimulation appeared at relatively high stimulus intensities (> 50 mA); conditioning cutaneous stimulation left it unchanged, and the inhibition had a short recovery cycle (50 ms). Tendon stimulation still evoked EMG suppression during an ischaemic block of fast-conducting afferents. The motor potentials evoked by transcranial magnetic stimulation of the motor cortex during the EMG silence remained almost unchanged, whereas the H reflex was strongly inhibited. Hence we conclude that tendon stimulation activities slow-conducting tendon afferents, possibly group III fibres, connected not through a polysynaptic pathway origination from Ib afferents but through an oligo- or disynaptic inhibitory circuit. The EMG suppression after tendon stimulation probably represents a dysfacilitation of the α-motor neurons due to presynaptic inhibition of Ia fibres produced by tendon afferent input to the spinal cord.

Original languageEnglish
Pages (from-to)373-380
Number of pages8
JournalBrain
Volume121
Issue number2
DOIs
Publication statusPublished - Feb 1998

Fingerprint

Tendons
Electric Stimulation
Muscles
H-Reflex
Motor Evoked Potentials
Transcranial Magnetic Stimulation
Motor Cortex
Motor Neurons
Forearm
Spinal Cord
Healthy Volunteers
Skin

Keywords

  • Group III afferents
  • Ia afferents
  • Muscle tendon
  • Presynaptic inhibition
  • Silent period

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Electrical stimulation over muscle tendons in humans. Evidence favouring presynaptic inhibition of Ia fibres due to the activation of group III tendon afferents. / Priori, Alberto; Berardelli, Alfredo; Inghilleri, Maurizio; Pedace, Francesca; Giovannelli, Morena; Manfredi, Mario.

In: Brain, Vol. 121, No. 2, 02.1998, p. 373-380.

Research output: Contribution to journalArticle

Priori, Alberto ; Berardelli, Alfredo ; Inghilleri, Maurizio ; Pedace, Francesca ; Giovannelli, Morena ; Manfredi, Mario. / Electrical stimulation over muscle tendons in humans. Evidence favouring presynaptic inhibition of Ia fibres due to the activation of group III tendon afferents. In: Brain. 1998 ; Vol. 121, No. 2. pp. 373-380.
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