Electrically-elicited surface mechanomyogram in myotonic dystrophy

C. Orizio, F. Esposito, I. Paganotti, L. Marino, B. Rossi, A. Veicsteinas

Research output: Contribution to journalArticle

Abstract

The surface oscillation of the muscle during electrical stimulation is detectable by an accelerometer as a surface mechanomyogram (MMG). The aim of this study was to evaluate whether MMG properties reflect the mechanical muscle changes induced by myotonic dystrophy (MyD). To this end, the tibialis anterior of seven MyD patients and seven age- and sex-matched controls (C) was supramaximally stimulated at I (single twitches), 5, 10, 15, 20 Hz for 3 s at the most proximal motor point. Results Single twitches: The MMG amplitude was 67% less, the duration 37% longer, the electromechanical delay 64% longer, and the spectrum mean frequency 44% lower in the MyD patients than in controls. Repetitive stimulation At each stimulation frequency, the average MMG peak-to-peak was less in the MyD patients than in C. Conclusion The differences between the MMGs of MyD patients and C support the hypothesis that, together with the well-known changes in sarcolemmal excitability, an alteration in electromechanical coupling and a failure in contractile machinery may coexist in MyD.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

Keywords

  • Electro-mechanical coupling
  • Myotonic dystrophy
  • Stimulated muscle contraction
  • Surface mechanomyogram

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)

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  • Cite this

    Orizio, C., Esposito, F., Paganotti, I., Marino, L., Rossi, B., & Veicsteinas, A. (1997). Electrically-elicited surface mechanomyogram in myotonic dystrophy. Italian Journal of Neurological Sciences, 18(4), 185-190.