Electroactive polyurethane/siloxane derived from castor oil as a versatile cardiac patch, part I: Synthesis, characterization, and myoblast proliferation and differentiation

Nafiseh Baheiraei, Reza Gharibi, Hamid Yeganeh, Michele Miragoli, Nicolò Salvarani, Elisa Di Pasquale, Gianluigi Condorelli

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Tissue-engineered cardiac patch aims at regenerating an infarcted heart by improving cardiac function and providing mechanical support to the diseased myocardium. In order to take advantages of electroactivity, a new synthetic method was developed for the introduction of an electroactive oligoaniline into the backbone of prepared patches. For this purpose, a series of electroactive polyurethane/siloxane films containing aniline tetramer (AT) was prepared through sol-gel reaction of trimethoxysilane functional intermediate polyurethane prepolymers made from castor oil and poly(ethylene glycol). Physicochemical, mechanical, and electrical conductivity of samples were evaluated and the recorded results were correlated to their structural characteristics. The optimized films were proved to be biodegradable and have tensile properties suitable for cardiac patch application. The embedded AT moieties in the backbone of the prepared samples preserved their electroactivity with the electrical conductivity in the range of 10-4 S/cm. The prepared films were compatible with proliferation of C2C12 and had potential for enhancing myotube formation even without external electrical stimulation.

Original languageEnglish
Pages (from-to)775-787
Number of pages13
JournalJournal of Biomedical Materials Research - Part A
Volume104
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Fingerprint

Castor Oil
Siloxanes
Electric Conductivity
Polyurethanes
Myoblasts
Aniline
Ethylene Glycol
Skeletal Muscle Fibers
Polymethyl Methacrylate
Electric Stimulation
Myocardium
Gels
Tensile properties
Polyethylene glycols
Sol-gels
Tissue
aniline
Oils
trimethoxysilane

Keywords

  • aniline tetramer
  • C2C12 myoblast
  • cardiac patch
  • castor oil
  • polyurethane

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Metals and Alloys

Cite this

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abstract = "Tissue-engineered cardiac patch aims at regenerating an infarcted heart by improving cardiac function and providing mechanical support to the diseased myocardium. In order to take advantages of electroactivity, a new synthetic method was developed for the introduction of an electroactive oligoaniline into the backbone of prepared patches. For this purpose, a series of electroactive polyurethane/siloxane films containing aniline tetramer (AT) was prepared through sol-gel reaction of trimethoxysilane functional intermediate polyurethane prepolymers made from castor oil and poly(ethylene glycol). Physicochemical, mechanical, and electrical conductivity of samples were evaluated and the recorded results were correlated to their structural characteristics. The optimized films were proved to be biodegradable and have tensile properties suitable for cardiac patch application. The embedded AT moieties in the backbone of the prepared samples preserved their electroactivity with the electrical conductivity in the range of 10-4 S/cm. The prepared films were compatible with proliferation of C2C12 and had potential for enhancing myotube formation even without external electrical stimulation.",
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AU - Gharibi, Reza

AU - Yeganeh, Hamid

AU - Miragoli, Michele

AU - Salvarani, Nicolò

AU - Di Pasquale, Elisa

AU - Condorelli, Gianluigi

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