Electrocardiographic changes in HIV-infected, drug-experienced patients being treated with atazanavir

Nicola Gianotti; Monica Guffanti; Laura Galli; Alberto Margonato; Giulia Chiaravalli; Alba Bigoloni; Adriano Lazzarin; Antonella Castagna

doi:10.1097/QAD.0b013e32826fbc6a

Electrocardiographic changes in HIV-infected, drug-experienced patients being treated with atazanavir

Nicola Gianotti, Monica Guffanti, Laura Galli, Alberto Margonato, Giulia Chiaravalli, Alba Bigoloni, Adriano Lazzarin, Antonella Castagna

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The QRS interval of 56 out of 75 (74.7%) HIV-infected, drug-experienced patients (66.7% men) increased during treatment with boosted or unboosted atazanavir by a median 5 ms (interquartile range 0-9; P <0.0001); the PR and the QTc intervals did not change significantly. New asymptomatic bundle branch blocks were observed in four patients; one subject with a baseline first-degree atrioventricular block developed symptomatic bradyarrhythmia while receiving atenolol. The electrocardiographic monitoring of patients treated with atazanavir seems advisable.

Original language	English
Pages (from-to)	1648-1651
Number of pages	4
Journal	AIDS (London, England)
Volume	21
Issue number	12
DOIs	https://doi.org/10.1097/QAD.0b013e32826fbc6a
Publication status	Published - Jul 2007

ASJC Scopus subject areas

Immunology
Immunology and Allergy

Access to Document

10.1097/QAD.0b013e32826fbc6a

Cite this

@article{05c86744c12c4f4db956318a80d1dc3b,

title = "Electrocardiographic changes in HIV-infected, drug-experienced patients being treated with atazanavir",

abstract = "The QRS interval of 56 out of 75 (74.7%) HIV-infected, drug-experienced patients (66.7% men) increased during treatment with boosted or unboosted atazanavir by a median 5 ms (interquartile range 0-9; P <0.0001); the PR and the QTc intervals did not change significantly. New asymptomatic bundle branch blocks were observed in four patients; one subject with a baseline first-degree atrioventricular block developed symptomatic bradyarrhythmia while receiving atenolol. The electrocardiographic monitoring of patients treated with atazanavir seems advisable.",

author = "Nicola Gianotti and Monica Guffanti and Laura Galli and Alberto Margonato and Giulia Chiaravalli and Alba Bigoloni and Adriano Lazzarin and Antonella Castagna",

year = "2007",

month = jul,

doi = "10.1097/QAD.0b013e32826fbc6a",

language = "English",

volume = "21",

pages = "1648--1651",

journal = "AIDS",

issn = "0269-9370",

publisher = "NLM (Medline)",

number = "12",

}

TY - JOUR

T1 - Electrocardiographic changes in HIV-infected, drug-experienced patients being treated with atazanavir

AU - Gianotti, Nicola

AU - Guffanti, Monica

AU - Galli, Laura

AU - Margonato, Alberto

AU - Chiaravalli, Giulia

AU - Bigoloni, Alba

AU - Lazzarin, Adriano

AU - Castagna, Antonella

PY - 2007/7

Y1 - 2007/7

N2 - The QRS interval of 56 out of 75 (74.7%) HIV-infected, drug-experienced patients (66.7% men) increased during treatment with boosted or unboosted atazanavir by a median 5 ms (interquartile range 0-9; P <0.0001); the PR and the QTc intervals did not change significantly. New asymptomatic bundle branch blocks were observed in four patients; one subject with a baseline first-degree atrioventricular block developed symptomatic bradyarrhythmia while receiving atenolol. The electrocardiographic monitoring of patients treated with atazanavir seems advisable.

AB - The QRS interval of 56 out of 75 (74.7%) HIV-infected, drug-experienced patients (66.7% men) increased during treatment with boosted or unboosted atazanavir by a median 5 ms (interquartile range 0-9; P <0.0001); the PR and the QTc intervals did not change significantly. New asymptomatic bundle branch blocks were observed in four patients; one subject with a baseline first-degree atrioventricular block developed symptomatic bradyarrhythmia while receiving atenolol. The electrocardiographic monitoring of patients treated with atazanavir seems advisable.

UR - http://www.scopus.com/inward/record.url?scp=34447566881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447566881&partnerID=8YFLogxK

U2 - 10.1097/QAD.0b013e32826fbc6a

DO - 10.1097/QAD.0b013e32826fbc6a

M3 - Article

C2 - 17630564

AN - SCOPUS:34447566881

VL - 21

SP - 1648

EP - 1651

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 12

ER -

Electrocardiographic changes in HIV-infected, drug-experienced patients being treated with atazanavir

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this