Electrocardiographic features of sudden unexpected death in epilepsy

Janice Y. Chyou, Daniel Friedman, Marina Cerrone, William Slater, Yu Guo, Daniel Taupin, Sean O'Rourke, Silvia G. Priori, Orrin Devinsky

Research output: Contribution to journalArticlepeer-review


Sudden unexpected death in epilepsy (SUDEP) is the most common cause of epilepsy-related mortality. We hypothesized that electrocardiography (ECG) features may distinguish SUDEP cases from living subjects with epilepsy. Using a matched case–control design, we compared ECG studies of 12 consecutive cases of SUDEP over 10 years and 22 epilepsy controls matched for age, sex, epilepsy type (focal, generalized, or unknown/mixed type), concomitant antiepileptic, and psychotropic drug classes. Conduction intervals and prevalence of abnormal ventricular conduction diagnosis (QRS ≥110 msec), abnormal ventricular conduction pattern (QRS

Original languageEnglish
Pages (from-to)e135-e139
Issue number7
Publication statusPublished - Jul 1 2016


  • All epilepsy/seizures
  • Cardiac
  • Electrocardiogram
  • Risk factors in epidemiology
  • Sudden death

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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