Electrochemotherapy - A locoregional therapy with well-established palliative effect in patient with large recurrent lesion of head and neck

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Abstract

BACKGROUND: Electrochemotherapy (ECT) is a well established treatment strategy for skin tumors of different histology. The aim of this study was to evaluate the feasibility and efficacy of electrochemotherapy in the palliative setting in patients with head and neck malignancies, already treated with surgery and/or radio-chemotherapy with no other therapeutic option.

METHODS: Thirty-six patients with a loco-regional M0/M1 relapse with no other therapeutic option not suitable for a cure with a radical intent by surgery or RT and not suitable for systemic therapy and/or already treated with it, were admitted to electrochemotherapy (ECT) protocol treatment. ECT was performed according ESOPE guidelines. Clinical features, treatment response, and adverse effects were evaluated 15, 30 days and then every months after the treatment.

RESULTS: An overall response of 100% was observed. Only 3 patients out 36 showed a CR. Overall survival probability at 12 months was 41.6% (median OS: 9 months). In all patient, an improvement of quality of life in terms of pain, bleeding events were observed, while need for medical assistance or dressing was significantly reduced 1 month after electrochemotherapy (p < 0.001).

CONCLUSIONS: Electrochemotherapy is an effective palliative treatment of non-resectable head and neck malignancies able. Due to the ECT limited side effects, its early use would be desirable to obtain a better local control of the disease and improve quality of life of patients.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalJournal of Maxillofacial Surgery
Volume47
Issue number1
DOIs
Publication statusPublished - Jan 2019

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Electrochemotherapy
Neck
Head
Therapeutics
Quality of Life
Medical Assistance
Neoplasms
Bandages
Clinical Protocols
Radio
Palliative Care
Histology
Guidelines
Hemorrhage
Recurrence
Drug Therapy
Pain
Skin
Survival

Cite this

@article{6975371613f94850aaa8c1b1004abb65,
title = "Electrochemotherapy - A locoregional therapy with well-established palliative effect in patient with large recurrent lesion of head and neck",
abstract = "BACKGROUND: Electrochemotherapy (ECT) is a well established treatment strategy for skin tumors of different histology. The aim of this study was to evaluate the feasibility and efficacy of electrochemotherapy in the palliative setting in patients with head and neck malignancies, already treated with surgery and/or radio-chemotherapy with no other therapeutic option.METHODS: Thirty-six patients with a loco-regional M0/M1 relapse with no other therapeutic option not suitable for a cure with a radical intent by surgery or RT and not suitable for systemic therapy and/or already treated with it, were admitted to electrochemotherapy (ECT) protocol treatment. ECT was performed according ESOPE guidelines. Clinical features, treatment response, and adverse effects were evaluated 15, 30 days and then every months after the treatment.RESULTS: An overall response of 100{\%} was observed. Only 3 patients out 36 showed a CR. Overall survival probability at 12 months was 41.6{\%} (median OS: 9 months). In all patient, an improvement of quality of life in terms of pain, bleeding events were observed, while need for medical assistance or dressing was significantly reduced 1 month after electrochemotherapy (p < 0.001).CONCLUSIONS: Electrochemotherapy is an effective palliative treatment of non-resectable head and neck malignancies able. Due to the ECT limited side effects, its early use would be desirable to obtain a better local control of the disease and improve quality of life of patients.",
author = "Barbara Pichi and Raul Pellini and Giuseppe Spriano",
note = "Copyright {\circledC} 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.",
year = "2019",
month = "1",
doi = "10.1016/j.jcms.2018.10.014",
language = "English",
volume = "47",
pages = "41--46",
journal = "Journal of Maxillofacial Surgery",
issn = "1010-5182",
publisher = "Churchill Livingstone",
number = "1",

}

TY - JOUR

T1 - Electrochemotherapy - A locoregional therapy with well-established palliative effect in patient with large recurrent lesion of head and neck

AU - Pichi, Barbara

AU - Pellini, Raul

AU - Spriano, Giuseppe

N1 - Copyright © 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

PY - 2019/1

Y1 - 2019/1

N2 - BACKGROUND: Electrochemotherapy (ECT) is a well established treatment strategy for skin tumors of different histology. The aim of this study was to evaluate the feasibility and efficacy of electrochemotherapy in the palliative setting in patients with head and neck malignancies, already treated with surgery and/or radio-chemotherapy with no other therapeutic option.METHODS: Thirty-six patients with a loco-regional M0/M1 relapse with no other therapeutic option not suitable for a cure with a radical intent by surgery or RT and not suitable for systemic therapy and/or already treated with it, were admitted to electrochemotherapy (ECT) protocol treatment. ECT was performed according ESOPE guidelines. Clinical features, treatment response, and adverse effects were evaluated 15, 30 days and then every months after the treatment.RESULTS: An overall response of 100% was observed. Only 3 patients out 36 showed a CR. Overall survival probability at 12 months was 41.6% (median OS: 9 months). In all patient, an improvement of quality of life in terms of pain, bleeding events were observed, while need for medical assistance or dressing was significantly reduced 1 month after electrochemotherapy (p < 0.001).CONCLUSIONS: Electrochemotherapy is an effective palliative treatment of non-resectable head and neck malignancies able. Due to the ECT limited side effects, its early use would be desirable to obtain a better local control of the disease and improve quality of life of patients.

AB - BACKGROUND: Electrochemotherapy (ECT) is a well established treatment strategy for skin tumors of different histology. The aim of this study was to evaluate the feasibility and efficacy of electrochemotherapy in the palliative setting in patients with head and neck malignancies, already treated with surgery and/or radio-chemotherapy with no other therapeutic option.METHODS: Thirty-six patients with a loco-regional M0/M1 relapse with no other therapeutic option not suitable for a cure with a radical intent by surgery or RT and not suitable for systemic therapy and/or already treated with it, were admitted to electrochemotherapy (ECT) protocol treatment. ECT was performed according ESOPE guidelines. Clinical features, treatment response, and adverse effects were evaluated 15, 30 days and then every months after the treatment.RESULTS: An overall response of 100% was observed. Only 3 patients out 36 showed a CR. Overall survival probability at 12 months was 41.6% (median OS: 9 months). In all patient, an improvement of quality of life in terms of pain, bleeding events were observed, while need for medical assistance or dressing was significantly reduced 1 month after electrochemotherapy (p < 0.001).CONCLUSIONS: Electrochemotherapy is an effective palliative treatment of non-resectable head and neck malignancies able. Due to the ECT limited side effects, its early use would be desirable to obtain a better local control of the disease and improve quality of life of patients.

U2 - 10.1016/j.jcms.2018.10.014

DO - 10.1016/j.jcms.2018.10.014

M3 - Article

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SP - 41

EP - 46

JO - Journal of Maxillofacial Surgery

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