Electrochemotherapy for cutaneous and subcutaneous tumor lesions: A novel therapeutic approach

Alessandro Testori, Giulio Tosti, Chiara Martinoli, Giuseppe Spadola, Francesco Cataldo, Francesco Verrecchia, Federica Baldini, Massimo Mosconi, Javier Soteldo, Ines Tedeschi, Claudia Passoni, Chiara Pari, Alessandra Di Pietro, Pier Francesco Ferrucci

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Electroporation uses pulsed, high-intensity electric fields to temporarily increase cell membrane permeability by creation of pores, through which small molecules, such as chemotherapeutic agents, can diffuse inside cells before they reseal. The combination of electroporation with the administration of otherwise low-permeant cytotoxic drugs is known as electrochemotherapy (ECT). The two most commonly used drugs are bleomycin and cisplatin. ECT has already been proven to be effective in diverse tumor histotypes, including melanoma and basal and squamous cell carcinoma, Kaposi sarcoma, and breast cancer, also in those cases nonresponding to classical chemotherapies or other loco-regional treatment modalities, with a good safety profile. ECT can be proposed as loco-regional therapy for disseminated cutaneous and subcutaneous tumor lesions as alternative treatment modality to conventional therapies or as palliative care, in order to improve patients' quality of life.

Original languageEnglish
Pages (from-to)651-661
Number of pages11
JournalDermatologic Therapy
Volume23
Issue number6
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Electrochemotherapy
Skin
Electroporation
Neoplasms
Cell Membrane Permeability
Kaposi's Sarcoma
Basal Cell Carcinoma
Bleomycin
Therapeutics
Palliative Care
Pharmaceutical Preparations
Cisplatin
Squamous Cell Carcinoma
Melanoma
Quality of Life
Breast Neoplasms
Safety
Drug Therapy

Keywords

  • electrochemotherapy
  • melanoma
  • primary skin tumors
  • skin metastases
  • subcutaneous lesions

ASJC Scopus subject areas

  • Dermatology

Cite this

Electrochemotherapy for cutaneous and subcutaneous tumor lesions : A novel therapeutic approach. / Testori, Alessandro; Tosti, Giulio; Martinoli, Chiara; Spadola, Giuseppe; Cataldo, Francesco; Verrecchia, Francesco; Baldini, Federica; Mosconi, Massimo; Soteldo, Javier; Tedeschi, Ines; Passoni, Claudia; Pari, Chiara; Di Pietro, Alessandra; Ferrucci, Pier Francesco.

In: Dermatologic Therapy, Vol. 23, No. 6, 11.2010, p. 651-661.

Research output: Contribution to journalArticle

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