Electrochemotherapy for localized lymphoma: A preliminary study in companion animals

E. P. Spugnini, G. Citro, P. Mellone, I. Dotsinsky, N. Mudrov, A. Baldi

Research output: Contribution to journalArticle

Abstract

Non Hogdkin's lymphoma is the commonest malignant neoplasm in humans and in pets. Treatments include systemic chemotherapy eventually combined with radiation therapy. Radiation therapy is also used as single agent for the treatment of localized lymphoma (LSA). Albeit efficacious, this modality is potentially associated with side effects. Purpose of this study was to preliminarily evaluate the feasibility and efficacy of electrochemotherapy (ECT) in companion animals with localized lymphoma. Six patients entered the study and received two sessions of ECT under sedation. The pets had local injection of bleomycin at the concentration of 1.5 mg/mg and five minutes after the chemotherapy, trains of 8 biphasic electric pulses lasting 50 + 50 μs each, with 1 ms interpulse intervals, were delivered by means of modified caliper electrodes or for difficult districts, through paired needle electrode. All the patients achieved complete responses (lasting 1 week through 3 years), one cat with nasal LSA had local recurrence and two others experienced spinal and intestinal relapse. Side effects were not noted with the exception of focal alopecia in a cat with retrobulbar LSA. Electrochemotherapy appears as a safe and efficacious modality for the treatment of localized lymphoma and warrants further investigations.

Original languageEnglish
Pages (from-to)343-346
Number of pages4
JournalJournal of Experimental and Clinical Cancer Research
Volume26
Issue number3
Publication statusPublished - Sep 2007

Keywords

  • Biphasic pulses
  • Bleomycin
  • Electrochemotherapy
  • Lymphoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Spugnini, E. P., Citro, G., Mellone, P., Dotsinsky, I., Mudrov, N., & Baldi, A. (2007). Electrochemotherapy for localized lymphoma: A preliminary study in companion animals. Journal of Experimental and Clinical Cancer Research, 26(3), 343-346.