Electrochemotherapy for the Treatment of Multiple Melanomas in a Horse

Enrico P. Spugnini, Gian Lorenzo D' Alterio, Ivan Dotsinsky, Tzvetan Mudrov, Emanuele Dragonetti, Raffaele Murace, Gennaro Citro, Alfonso Baldi

Research output: Contribution to journalArticlepeer-review


A 22-year-old Camargue mare was referred for showing signs of discomfort during chewing, building up of food in the mouth, and foul odor from the mouth. On physical examination, the mare presented bilateral pigmented labial masses affecting the upper and lower lips, more in the form of plaques at the mucocutaneous junction as well as multiple perivulvar and perianal lumps. The skin lesions were biopsied for histopathologic examination and the clinical suspect of melanoma was confirmed. The owner elected the lesions to be treated with electrochemotherapy using the drug cisplatin. After two sessions, the nodules were shrunk by 50% and the horse's ability to feed normally was restored: at that time, the owner had the treatment discontinued because of financial issues. The horse is still in partial remission after 1 year from the end of the treatment. Electrochemotherapy can be successfully used to palliate large melanomas in horses.

Original languageEnglish
Pages (from-to)430-433
Number of pages4
JournalJournal of Equine Veterinary Science
Issue number8
Publication statusPublished - Aug 2011


  • Biphasic pulses
  • Cisplatin
  • Horse
  • Melanoma
  • Portable equipment

ASJC Scopus subject areas

  • Equine


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