Electrochemotherapy for the treatment of squamous cell carcinoma in cats: A preliminary report

Enrico P. Spugnini, Bruno Vincenzi, Gennaro Citro, Giuseppe Tonini, Ivan Dotsinsky, Nikolay Mudrov, Alfonso Baldi

Research output: Contribution to journalArticlepeer-review

Abstract

Squamous cell carcinomas (SCC) of the skin are commonly described in cats. Reported treatments include surgery, radiation therapy and photodynamic therapy. This preliminary study reports on the management of these lesions combining the local administration of bleomycin (plus hyaluronidase for a more uniform distribution) with permeabilizing biphasic electric pulses. Nine cats with SCC graded T2-T4 were treated over a 5 year period, and each cat received two sessions of electrochemotherapy (ECT) 1 week apart. The side effects of this treatment were minimal and limited to mild erythema of the nose. Seven of the cats (77.7%) had a complete response lasting up to 3 years. ECT seems to be a safe and effective option for the treatment of feline sun-induced squamous cell carcinomas and warrants further investigation.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalVeterinary Journal
Volume179
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Bleomycin
  • Carcinoma
  • Electrochemotherapy
  • Feline
  • Hyaluronidase

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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