Electrochemotherapy in non-melanoma head and neck cancers: a retrospective analysis of the treated cases

Luca G iovanni Campana, Barbara Mali, Gregor Sersa, Sara Valpione, Carlo A. Giorgi, Primoz Strojan, Damijan Miklavcic, Carlo R. Rossi

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Electrochemotherapy increases the permeability of tumours to drugs by electric voltages applied locally. Its value in tumours of the head and neck is unknown. We retrospectively reviewed a 2-centre database, and found 39 patients with squamous cell carcinoma (SCC) of the oral cavity or oropharynx (n=12) or non-melanoma skin tumours (n=27) who had been treated with bleomycin electrochemotherapy with needle electrodes. A further 3 patients were given cisplatin electrochemotherapy (n=2), or bleomycin electrochemotherapy by plate electrodes (n=1). Local toxicity was mild. The complete response rate was 38% and was associated with whether the tumour was primary or recurrent (p

Original languageEnglish
Pages (from-to)957-964
Number of pages8
JournalBritish Journal of Oral and Maxillofacial Surgery
Volume52
Issue number10
DOIs
Publication statusPublished - Dec 1 2014

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Electrochemotherapy
Head and Neck Neoplasms
Bleomycin
Neoplasms
Electrodes
Oropharynx
Cisplatin
Needles
Mouth
Squamous Cell Carcinoma
Permeability
Neck
Head
Databases
Skin
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

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Electrochemotherapy in non-melanoma head and neck cancers : a retrospective analysis of the treated cases. / Campana, Luca G iovanni; Mali, Barbara; Sersa, Gregor; Valpione, Sara; Giorgi, Carlo A.; Strojan, Primoz; Miklavcic, Damijan; Rossi, Carlo R.

In: British Journal of Oral and Maxillofacial Surgery, Vol. 52, No. 10, 01.12.2014, p. 957-964.

Research output: Contribution to journalArticle

Campana, Luca G iovanni ; Mali, Barbara ; Sersa, Gregor ; Valpione, Sara ; Giorgi, Carlo A. ; Strojan, Primoz ; Miklavcic, Damijan ; Rossi, Carlo R. / Electrochemotherapy in non-melanoma head and neck cancers : a retrospective analysis of the treated cases. In: British Journal of Oral and Maxillofacial Surgery. 2014 ; Vol. 52, No. 10. pp. 957-964.
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