Electrochemotherapy in non-melanoma head and neck cancers: a retrospective analysis of the treated cases

Luca G iovanni Campana, Barbara Mali, Gregor Sersa, Sara Valpione, Carlo A. Giorgi, Primoz Strojan, Damijan Miklavcic, Carlo R. Rossi

Research output: Contribution to journalArticlepeer-review

Abstract

Electrochemotherapy increases the permeability of tumours to drugs by electric voltages applied locally. Its value in tumours of the head and neck is unknown. We retrospectively reviewed a 2-centre database, and found 39 patients with squamous cell carcinoma (SCC) of the oral cavity or oropharynx (n=12) or non-melanoma skin tumours (n=27) who had been treated with bleomycin electrochemotherapy with needle electrodes. A further 3 patients were given cisplatin electrochemotherapy (n=2), or bleomycin electrochemotherapy by plate electrodes (n=1). Local toxicity was mild. The complete response rate was 38% and was associated with whether the tumour was primary or recurrent (p

Original languageEnglish
Pages (from-to)957-964
Number of pages8
JournalBritish Journal of Oral and Maxillofacial Surgery
Volume52
Issue number10
DOIs
Publication statusPublished - Dec 1 2014

ASJC Scopus subject areas

  • Medicine(all)

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