Electrochemotherapy in oncology reconstructive surgery: Five cases preliminary report

J. Tassinari, G. Orlandino, R. Ardito, T. Fabrizio

Research output: Contribution to journalArticle

Abstract

Electrochemotherapy (ECT) is a new terapeuc opportunity, effective and easy for local treatment of skin and subcutaneous cancer independlly by histology. It is the result of the combination of two effects: reduced injection of drug dose and electroporation of the cellular membrane; it is based on the local application of short and intense electrical impulses, which make reversibly the cellular membrane permeable, facilitate the income of the drug in the cancer cell, improve the cytotoxic effects to the exposed tissues. In this way the dose of the drug will be inferior to a standard chemotherapy treatment. The more suitable drugs for the ECT are the bleomycin and the cisplatin using local or general anesthesia. The ECT could be used to patients with single or multiple lesions like basal cell carcinoma, squamous cell carcinoma, metastases, Kaposi sarcoma, melanoma. It showes its effectiveness: to reduce the dimension of the painful and/or bleeding surgical mass due to cutaneous or subcutaneous metastases. Our plan of search is compost of five cases of skin cancer and soft tissue tumors normally considered inoperable or not answering to traditional complementary therapies. The scope of this new method is the reduction of the dimensions of the cancer or the eventual bleeding, the creation of a surgical plan initially non existent in order to perform the surgical removal. The preliminary results are presented.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalRivista Italiana di Chirurgia Plastica
Volume40
Issue number1-2
Publication statusPublished - 2008

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ASJC Scopus subject areas

  • Surgery

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Tassinari, J., Orlandino, G., Ardito, R., & Fabrizio, T. (2008). Electrochemotherapy in oncology reconstructive surgery: Five cases preliminary report. Rivista Italiana di Chirurgia Plastica, 40(1-2), 55-60.