Abstract
Electrochemotherapy is gaining popularity for the treatment of malignancies of companion animals due to its efficacy and low cost. In this paper, we describe the successful treatment of a recurring fibrosarcoma in a cat by using cisplatin selectively driven within the tumor cells by trains of biphasic pulses. The cat's tumor did not recur over the following five months, however the cat did experience severe erythema at the site of previous irradiation, followed by moist desquamation and ulcer that required debridement and prolonged therapy with steroids and antihistaminic drugs. The symptoms and the response to symptomatic therapy were strongly suggestive of radiation recall. Electrochemotherapy (ECT) should be used with caution in previously irradiated areas. Further studies are warranted in this field due to its potential as a rescue for relapsing tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 751-754 |
| Number of pages | 4 |
| Journal | In Vivo |
| Volume | 22 |
| Issue number | 6 |
| Publication status | Published - Nov 2008 |
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Keywords
- Biphasic pulses
- Cat
- Cisplatin
- Fibrosarcoma
- Radiation recall
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology
Cite this
Electrochemotherapy-induced radiation recall in a cat. / Spugnini, Enrico P.; Dotsinsky, Ivan; Mudrov, Nikolay; Citro, Gennaro; Caruso, Giovanni; Cardelli, Pierluigi; Baldi, Alfonso.
In: In Vivo, Vol. 22, No. 6, 11.2008, p. 751-754.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Electrochemotherapy-induced radiation recall in a cat
AU - Spugnini, Enrico P.
AU - Dotsinsky, Ivan
AU - Mudrov, Nikolay
AU - Citro, Gennaro
AU - Caruso, Giovanni
AU - Cardelli, Pierluigi
AU - Baldi, Alfonso
PY - 2008/11
Y1 - 2008/11
N2 - Electrochemotherapy is gaining popularity for the treatment of malignancies of companion animals due to its efficacy and low cost. In this paper, we describe the successful treatment of a recurring fibrosarcoma in a cat by using cisplatin selectively driven within the tumor cells by trains of biphasic pulses. The cat's tumor did not recur over the following five months, however the cat did experience severe erythema at the site of previous irradiation, followed by moist desquamation and ulcer that required debridement and prolonged therapy with steroids and antihistaminic drugs. The symptoms and the response to symptomatic therapy were strongly suggestive of radiation recall. Electrochemotherapy (ECT) should be used with caution in previously irradiated areas. Further studies are warranted in this field due to its potential as a rescue for relapsing tumors.
AB - Electrochemotherapy is gaining popularity for the treatment of malignancies of companion animals due to its efficacy and low cost. In this paper, we describe the successful treatment of a recurring fibrosarcoma in a cat by using cisplatin selectively driven within the tumor cells by trains of biphasic pulses. The cat's tumor did not recur over the following five months, however the cat did experience severe erythema at the site of previous irradiation, followed by moist desquamation and ulcer that required debridement and prolonged therapy with steroids and antihistaminic drugs. The symptoms and the response to symptomatic therapy were strongly suggestive of radiation recall. Electrochemotherapy (ECT) should be used with caution in previously irradiated areas. Further studies are warranted in this field due to its potential as a rescue for relapsing tumors.
KW - Biphasic pulses
KW - Cat
KW - Cisplatin
KW - Fibrosarcoma
KW - Radiation recall
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UR - http://www.scopus.com/inward/citedby.url?scp=57849117460&partnerID=8YFLogxK
M3 - Article
C2 - 19181001
AN - SCOPUS:57849117460
VL - 22
SP - 751
EP - 754
JO - In Vivo
JF - In Vivo
SN - 0258-851X
IS - 6
ER -