Electrochemotherapy-induced radiation recall in a cat

Enrico P. Spugnini, Ivan Dotsinsky, Nikolay Mudrov, Gennaro Citro, Giovanni Caruso, Pierluigi Cardelli, Alfonso Baldi

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Abstract

Electrochemotherapy is gaining popularity for the treatment of malignancies of companion animals due to its efficacy and low cost. In this paper, we describe the successful treatment of a recurring fibrosarcoma in a cat by using cisplatin selectively driven within the tumor cells by trains of biphasic pulses. The cat's tumor did not recur over the following five months, however the cat did experience severe erythema at the site of previous irradiation, followed by moist desquamation and ulcer that required debridement and prolonged therapy with steroids and antihistaminic drugs. The symptoms and the response to symptomatic therapy were strongly suggestive of radiation recall. Electrochemotherapy (ECT) should be used with caution in previously irradiated areas. Further studies are warranted in this field due to its potential as a rescue for relapsing tumors.

Original languageEnglish
Pages (from-to)751-754
Number of pages4
JournalIn Vivo
Volume22
Issue number6
Publication statusPublished - Nov 2008

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Keywords

  • Biphasic pulses
  • Cat
  • Cisplatin
  • Fibrosarcoma
  • Radiation recall

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Spugnini, E. P., Dotsinsky, I., Mudrov, N., Citro, G., Caruso, G., Cardelli, P., & Baldi, A. (2008). Electrochemotherapy-induced radiation recall in a cat. In Vivo, 22(6), 751-754.