Abstract
The fractional release technique was applied to investigate the effects of single electroshock (ECS) on the opioid-mediated inhibition of dopamine release in rat striatal slices. Animals were submitted to ECS 24 h before the experiments. The results demonstrate that pre-treatment with ECS suppresses the inhibition of dopamine release mediated by κ opioid receptors. These data suggest that single ECS treatment modifies the sensitivity of the κ opioid receptors located on the presynatic dopamine terminals in the rat striatum.
| Original language | English |
|---|---|
| Pages (from-to) | 805-810 |
| Number of pages | 6 |
| Journal | Journal of Neural Transmission |
| Volume | 104 |
| Issue number | 8-9 |
| Publication status | Published - 1997 |
Keywords
- Dopamine release
- ECS
- Opioids
- Striatum
ASJC Scopus subject areas
- Neuroscience(all)