Electroconvulsive shock blocks the opioid-mediated inhibition of dopamine release in rat striatal slices

F. Passarelli, E. Carmenini, L. Calò, F. Orzi, F. E. Pontieri

Research output: Contribution to journalArticlepeer-review

Abstract

The fractional release technique was applied to investigate the effects of single electroshock (ECS) on the opioid-mediated inhibition of dopamine release in rat striatal slices. Animals were submitted to ECS 24 h before the experiments. The results demonstrate that pre-treatment with ECS suppresses the inhibition of dopamine release mediated by κ opioid receptors. These data suggest that single ECS treatment modifies the sensitivity of the κ opioid receptors located on the presynatic dopamine terminals in the rat striatum.

Original languageEnglish
Pages (from-to)805-810
Number of pages6
JournalJournal of Neural Transmission
Volume104
Issue number8-9
Publication statusPublished - 1997

Keywords

  • Dopamine release
  • ECS
  • Opioids
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

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