The fractional release technique was applied to investigate the effects of single electroshock (ECS) on the opioid-mediated inhibition of dopamine release in rat striatal slices. Animals were submitted to ECS 24 h before the experiments. The results demonstrate that pre-treatment with ECS suppresses the inhibition of dopamine release mediated by κ opioid receptors. These data suggest that single ECS treatment modifies the sensitivity of the κ opioid receptors located on the presynatic dopamine terminals in the rat striatum.
|Number of pages||6|
|Journal||Journal of Neural Transmission|
|Publication status||Published - 1997|
- Dopamine release
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